The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
PCRA; domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 3: ATP-dependent DNA helicase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
8 P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P9WMQ1 (/IPI) P9WMQ1 (/IPI) P9WMQ1 (/IPI) P9WMQ1 (/IPI) P9WMQ1 (/IPI) P9WMQ1 (/IPI) P9WMQ1 (/IPI) P9WMQ1 (/IPI)
DNA-dependent ATPase activity GO:0008094
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
8 P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
8 P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA)
DATP binding GO:0032564
Interacting selectively and non-covalently with dATP, deoxyadenosine triphosphate.
8 P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA)
3'-5' DNA helicase activity GO:0043138
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'.
8 P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA)

There are 3 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
8 P9WMQ1 (/IMP) P9WMQ1 (/IMP) P9WMQ1 (/IMP) P9WMQ1 (/IMP) P9WMQ1 (/IMP) P9WMQ1 (/IMP) P9WMQ1 (/IMP) P9WMQ1 (/IMP)
UV protection GO:0009650
Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV.
8 P9WMQ1 (/IMP) P9WMQ1 (/IMP) P9WMQ1 (/IMP) P9WMQ1 (/IMP) P9WMQ1 (/IMP) P9WMQ1 (/IMP) P9WMQ1 (/IMP) P9WMQ1 (/IMP)
Negative regulation of strand invasion GO:0060543
Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.
8 P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
8 P9WMQ1 (/HDA) P9WMQ1 (/HDA) P9WMQ1 (/HDA) P9WMQ1 (/HDA) P9WMQ1 (/HDA) P9WMQ1 (/HDA) P9WMQ1 (/HDA) P9WMQ1 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 P9WMQ1 (/HDA) P9WMQ1 (/HDA) P9WMQ1 (/HDA) P9WMQ1 (/HDA) P9WMQ1 (/HDA) P9WMQ1 (/HDA) P9WMQ1 (/HDA) P9WMQ1 (/HDA)
DNA helicase complex GO:0033202
A protein complex that possesses DNA helicase activity.
8 P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA) P9WMQ1 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...