The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Calponin-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 55: MICAL-like protein 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 E1BBG2 (/IPI) Q3TN34 (/IPI) Q8BGT6 (/IPI) Q8IY33 (/IPI) Q8N3F8 (/IPI)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
3 Q3TN34 (/IPI) Q8BGT6 (/IPI) Q8N3F8 (/IPI)
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
3 D3ZQL6 (/ISS) E1BBG2 (/ISS) Q8BGT6 (/ISS)
Filamin binding GO:0031005
Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
2 Q3TN34 (/IDA) Q8IY33 (/IDA)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
2 D3ZEN0 (/ISS) Q8IY33 (/ISS)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 Q8BGT6 (/ISO)
Filamin binding GO:0031005
Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
1 Q3TN34 (/ISO)
Filamin binding GO:0031005
Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
1 D3ZEN0 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8N3F8 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8BGT6 (/ISO)
Actinin binding GO:0042805
Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.
1 Q3TN34 (/IPI)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 Q8N3F8 (/HDA)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q3TN34 (/IDA)
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
1 Q8N3F8 (/IDA)
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
1 Q8BGT6 (/ISO)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Swimming behavior GO:0036269
The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.
5 E5F2M9 (/IMP) F1QAZ3 (/IMP) F1REU8 (/IMP) Q6PFN3 (/IMP) Q7ZUX0 (/IMP)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
4 D3ZEN0 (/IMP) D3ZQL6 (/IMP) Q3TN34 (/IMP) Q8BGT6 (/IMP)
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
3 D3ZQL6 (/ISS) E1BBG2 (/ISS) Q8BGT6 (/ISS)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
3 D3ZQL6 (/ISS) E1BBG2 (/ISS) Q8BGT6 (/ISS)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
3 D3ZQL6 (/ISS) E1BBG2 (/ISS) Q8BGT6 (/ISS)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
3 E1BBG2 (/ISS) Q8IY33 (/ISS) Q8N3F8 (/ISS)
Slow endocytic recycling GO:0032458
The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport.
3 D3ZQL6 (/ISS) E1BBG2 (/ISS) Q8BGT6 (/ISS)
Plasma membrane tubulation GO:0097320
A membrane tubulation process occurring in a plasma membrane.
3 D3ZQL6 (/ISS) E1BBG2 (/ISS) Q8BGT6 (/ISS)
Retrograde transport, endosome to plasma membrane GO:1990126
The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
3 D3ZQL6 (/ISS) E1BBG2 (/ISS) Q8BGT6 (/ISS)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
2 D3ZEN0 (/IMP) Q3TN34 (/IMP)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 Q3TN34 (/ISO) Q8BGT6 (/ISO)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
2 D3ZEN0 (/ISS) Q8IY33 (/ISS)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
2 D3ZEN0 (/ISS) Q8IY33 (/ISS)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
2 D3ZEN0 (/ISS) Q8IY33 (/ISS)
Protein localization to endosome GO:0036010
A process in which a protein is transported to, or maintained in, a location within an endosome.
2 D3ZQL6 (/IMP) Q8N3F8 (/IMP)
Protein localization to endosome GO:0036010
A process in which a protein is transported to, or maintained in, a location within an endosome.
2 E1BBG2 (/ISS) Q8BGT6 (/ISS)
Bicellular tight junction assembly GO:0070830
The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.
2 D3ZEN0 (/ISS) Q8IY33 (/ISS)
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
1 Q8N3F8 (/IMP)
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
1 Q8BGT6 (/ISO)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
1 Q8N3F8 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
1 Q8BGT6 (/ISO)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
1 Q8N3F8 (/IMP)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
1 Q8BGT6 (/ISO)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
1 Q3TN34 (/ISO)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
1 Q8IY33 (/ISS)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q3TN34 (/IMP)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
1 Q3TN34 (/IDA)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
1 Q3TN34 (/IMP)
Slow endocytic recycling GO:0032458
The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport.
1 Q8N3F8 (/IMP)
Slow endocytic recycling GO:0032458
The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport.
1 Q8BGT6 (/ISO)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
1 Q3TN34 (/IMP)
Protein localization to endosome GO:0036010
A process in which a protein is transported to, or maintained in, a location within an endosome.
1 Q8BGT6 (/ISO)
Bicellular tight junction assembly GO:0070830
The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.
1 Q3TN34 (/IMP)
Plasma membrane tubulation GO:0097320
A membrane tubulation process occurring in a plasma membrane.
1 Q8N3F8 (/IDA)
Plasma membrane tubulation GO:0097320
A membrane tubulation process occurring in a plasma membrane.
1 Q8BGT6 (/ISO)
Positive regulation of protein targeting to mitochondrion GO:1903955
Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
1 Q8IY33 (/HMP)
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
1 D3ZQL6 (/IDA)
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
1 Q8BGT6 (/ISO)
Retrograde transport, endosome to plasma membrane GO:1990126
The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
1 Q8N3F8 (/IMP)
Retrograde transport, endosome to plasma membrane GO:1990126
The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
1 Q8BGT6 (/ISO)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
3 D3ZQL6 (/ISS) E1BBG2 (/ISS) Q8BGT6 (/ISS)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
3 D3ZQL6 (/ISS) E1BBG2 (/ISS) Q8BGT6 (/ISS)
Recycling endosome membrane GO:0055038
The lipid bilayer surrounding a recycling endosome.
3 D3ZQL6 (/ISS) E1BBG2 (/ISS) Q8BGT6 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 D3ZEN0 (/ISS) Q8IY33 (/ISS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
2 D3ZEN0 (/ISS) Q8IY33 (/ISS)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
2 D3ZEN0 (/ISS) Q8IY33 (/ISS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 Q3TN34 (/ISS) Q8IY33 (/ISS)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
2 D3ZEN0 (/ISS) Q8IY33 (/ISS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 Q8N3F8 (/IDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 Q8BGT6 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q3TN34 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q3TN34 (/IDA)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
1 Q3TN34 (/IDA)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 D3ZQL6 (/IDA)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 Q8BGT6 (/ISO)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q8N3F8 (/IDA)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q8BGT6 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 D3ZEN0 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q3TN34 (/ISO)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
1 Q3TN34 (/IDA)
Recycling endosome membrane GO:0055038
The lipid bilayer surrounding a recycling endosome.
1 Q8N3F8 (/IDA)
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