The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Calponin-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Microtubule-actin cross-linking factor 1smoothelin isoform X2Plastin-3 isoform 1Probable fimbrinNeuron navigator 2Plastin-3 isoform 1Probable fimbrinRelated to alpha-actininFimbrin-2 likeFimbrin-2 isoform AFimbrin, putativeFimbrin-1 isoform ARho guanine nucleotide exchange factor 7 isoform X1F-actin-methionine sulfoxide oxidase MICAL1 isoform X1Sperm flagellar protein 1Related to alpha-actininAlpha-actinin, sarcomericPLS3 isoform 7SC:2Hook homolog 3 (Drosophila)TransgelinCalponinProtein Hook homolog 3SC:3EH domain-binding protein 1 isoform X1protein-methionine sulfoxide oxidase MICAL3 isoform X1RP/EB family microtubule-associated proteinSC:4IQ motif containing GTPase activating protein 1Actinin alpha 1Spectrin beta chainSpectrin beta chainActinin alpha 4Filamin-B isoform AMicrotubule-associated protein, RP/EB family, member 2Filamin-B isoform CParvin, betaPlastin-3 isoform 1Plastin-3 isoform 1Parvin betaMicrotubule-actin cross-linking factor 1Vav guanine nucleotide exchange factor 2Cytospin-A isoform 1Leucine-rich repeat and calponin homology domain-containing protein 1 isoform 3Short stop, isoform Kplectin isoform X2Fimbrin-2 likeutrophin isoform X1nesprin-1 isoform X1girdin isoform X1Actinin alpha 1nesprin-1 isoform X1LIM and calponin homology domains-containing protein 1Spectrin beta chain, non-erythrocyticutrophin isoform X2Abnormal spindle-like microcephaly-associated protein homologGrowth arrest specific 2 like 1Short stop, isoform Bnesprin-2 isoform X2Abnormal spindle-like microcephaly-associated protein homologGrowth arrest specific 2nesprin-2 isoform X3Dixin isoform 1MICAL-like protein 2leucine-rich repeat and calponin homology domain-containing protein 4 isoform X2CalminRIKEN cDNA 6430531B16 geneSpermatogenesis associated 4Kinesin-like protein KIN-14I isoform ACalminParvin, gammap-loop nucleoside triphosphate hydrolase superfamily protein with CH (Calponin Homology) domainplastin-1 isoform X2kinesin-like protein KIN-14FPutative Filamin-Ap-loop nucleoside triphosphate hydrolase superfamily protein with CH (Calponin Homology) domainCalmodulin regulated spectrin-associated protein 1bplastin-1 isoform X1microtubule-associated protein RP/EB family member 2 isoform X2Kinesin-like protein KIN-14Lprotein sickie isoform X1TransgelinCoiled-coil domain containing 88BPutative Filamin-ANeuron navigator 3Fimbrin-2Leucine-rich-repeats and calponin homology domain protein, isoform Ccytospin-A isoform X2kinesin-like protein KIN-14J isoform X2Girdin, isoform Cprotein-methionine sulfoxide oxidase Mical isoform X3Fimbrin-like proteinp-loop nucleoside triphosphate hydrolase superfamily protein with CH (Calponin Homology) domainSpectrin beta chainKinesin-like protein KIN-14DFilamin BFimbrin, putativeGAS2-like protein 1Hook domain-containing proteinFimbrinParvin betaMicrotubule-associated protein EB1Uncharacterized proteinNuclear anchorage protein 1Kinesin-like protein KIN-14HTransgelinRelated to CDC24-GTP/GDP exchange factor for Cdc42pFimbrinFilamin 2, putativeMicrotubule End Binding ProteinScp1pM protein repeat proteinFimbrin, putativePatronin (microtubule-binding protein) homologUnplaced genomic scaffold supercont2.13, whole genome shotgun sequenceFimbrin, putativeMICAL like 1Ras GTPase-activating-like protein IQG1Protein Hook homolog 2Plastin 1Sperm flagellar protein 2p-loop nucleoside triphosphate hydrolase superfamily protein with CH (Calponin Homology) domainCalponin homology (CH) domain containing protein, putativeFimbrin-like protein 2-likeCalponin domain containing proteinCalponin domain containing proteinCoiled-coil domain containing 88CProtein CBR-UNC-53, isoform dCortexillin-2Uncharacterized proteinActin binding protein putativeCortexillin, putativeCRE-PAT-6 proteinCortexillin, putativeActinin alpha 1Dystrophin-1Actin binding protein putativePlectin bkinesin-4-likeDomain_of_Uncharacterized_Function_(DUF1042)_-_pu tativeUncharacterized proteinCortexillin ILeucine-rich Repeats (LRR) and Calponin Homology (CH) domain homologDystoninDNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2Neuron navigator 2Zygote defective protein 12Uncharacterized proteinWGS project CABT00000000 data, contig 2.3DystrophinEB1Alpha-parvinSmoothelin-like 1Ras GTPase-activating-like protein, IQGAP family member, putativeHook microtubule-tethering protein 2Uncharacterized proteinSperm antigen with calponin homology and coiled-coil domains 1girdinMicrotubule binding protein HOOK3, putative (AFU_orthologue AFUA_1G07490)Fimbrin, putativeUncharacterized proteinParvin, betaActinin, alpha 2bFimbrinFimbrinSerine/threonine-protein kinase pakDFimbrinUncharacterized proteinRac guanine nucleotide exchange factor BPredicted proteinDixinGuanine exchange factor for Rac 30Kinesin-like protein KIN-14GSi:ch211-207i1.2dixin isoform X1PlectinGelation factorUncharacterized proteinKinesin-like protein KIN-14G isoform APredicted proteinPredicted proteinPLaSTin (Actin bundling protein) homologLIM domain only protein 7Uncharacterized proteinGirdin homologUncharacterized proteinNeuron navigator 3Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinZgc:66426Coiled-coil domain containing 88AUncharacterized proteinPredicted proteinUncharacterized proteinGirdin, putativeLeucine-rich repeats and calponin homology (CH) domain-containing 3protein Hook homolog 3Uncharacterized proteinUncharacterized proteinInteraptinPlastin 2 putativeInteraptinActin bundling proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinEB1-like C-terminal motif containing protein, putativeMicrotubule-associated protein RP/EB family member 3Uncharacterized proteinUncharacterized proteinRac guanyl-nucleotide exchange factorPredicted proteinProtein Hook homolog 3Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPH domain-containing protein DDB_G0287875Predicted proteinPH domain-containing protein DDB_G0287875Uncharacterized proteinUncharacterized proteinp-loop nucleoside triphosphate hydrolase superfamily protein with CH (Calponin Homology) domainRac guanine nucleotide exchange factor BPlectinUncharacterized proteinUncharacterized proteinUncharacterized proteinMicrotubule-actin crosslinking factor 1PlectinSpectrin, beta, non-erythrocytic 5DIX domain-containing 1Uncharacterized proteinActinin alpha 1Uncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinCoiled-coil domain-containing 88AaUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinFlagellar associated proteinUncharacterized proteinSpectrin beta, non-erythrocytic 4Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinTransgelinMicrotubule-associated proteinUncharacterized proteinProtein hook homologPredicted proteinPredicted proteinPredicted proteinUncharacterized proteinUncharacterized proteinUtrophinUncharacterized proteinUncharacterized proteinPlastin 1Plastin 1Uncharacterized proteinFimbrin, putativeUncharacterized proteinUncharacterized proteinActinin alpha 1
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FunFam 162: Serine/threonine-protein kinase pakD

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 0 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
1 Q55DD4 (/IMP)
Aggregation involved in sorocarp development GO:0031152
The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
1 Q55DD4 (/IMP)
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
1 Q55DD4 (/IMP)
Chemotaxis to cAMP GO:0043327
The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP.
1 Q55DD4 (/IMP)
Negative regulation of filopodium assembly GO:0051490
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
1 Q55DD4 (/IMP)
Polyphosphate-mediated signaling GO:0110094
Any process that mediates the transfer of information from one cell to another using polyphosphate as the signal.
1 Q55DD4 (/IMP)
Negative regulation of asexual reproduction GO:1903665
Any process that stops, prevents or reduces the frequency, rate or extent of asexual reproduction.
1 Q55DD4 (/IMP)
Positive regulation of chemorepellent activity GO:1903669
Any process that activates or increases the frequency, rate or extent of chemorepellent activity.
1 Q55DD4 (/IMP)
Showing 1 to 8 of 8 entries

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Uropod GO:0001931
A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.
1 Q55DD4 (/IDA)
Pseudopodium GO:0031143
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.
1 Q55DD4 (/IDA)
Cell trailing edge GO:0031254
The area of a motile cell opposite to the direction of movement.
1 Q55DD4 (/IDA)
Showing 1 to 3 of 3 entries
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