View in Gene3D

CATH Superfamily 1.10.3860.10

Sodium:dicarboxylate symporter

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Sodium:dicarboxylate symporter
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: C4-dicarboxylate transport protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-aspartate transmembrane transporter activity GO:0015183
Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid.
 132 O59010 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA)
(122 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 131 P0A830 (/IPI) P0A830 (/IPI) P0A830 (/IPI) P0A830 (/IPI) P0A830 (/IPI) P0A830 (/IPI) P0A830 (/IPI) P0A830 (/IPI) P0A830 (/IPI) P0A830 (/IPI)
(121 more)
Fumarate transmembrane transporter activity GO:0015138
Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.
 131 P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP)
(121 more)
Succinate transmembrane transporter activity GO:0015141
Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other.
 131 P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP)
(121 more)
Malate:proton symporter activity GO:0015366
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in).
 131 P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA)
(121 more)
Solute:proton symporter activity GO:0015295
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in).
 29 A0A0F7RKN8 (/ISS) A0A0F7RKN8 (/ISS) A0A0F7RLL2 (/ISS) A0A0F7RLL2 (/ISS) A0A0F7RLL2 (/ISS) A0A0F7RLL2 (/ISS) A0A0F7RLL2 (/ISS) A0A1J9UYS5 (/ISS) A0A1J9UYS5 (/ISS) A0A1J9UYS5 (/ISS)
(19 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 6 Q88RJ2 (/IDA) Q88RJ2 (/IDA) Q88RJ2 (/IDA) Q88RJ2 (/IDA) Q88RJ2 (/IDA) Q88RJ2 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 6 Q88RJ2 (/IPI) Q88RJ2 (/IPI) Q88RJ2 (/IPI) Q88RJ2 (/IPI) Q88RJ2 (/IPI) Q88RJ2 (/IPI)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 6 Q88RJ2 (/IDA) Q88RJ2 (/IDA) Q88RJ2 (/IDA) Q88RJ2 (/IDA) Q88RJ2 (/IDA) Q88RJ2 (/IDA)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 6 Q88RJ2 (/IPI) Q88RJ2 (/IPI) Q88RJ2 (/IPI) Q88RJ2 (/IPI) Q88RJ2 (/IPI) Q88RJ2 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 2 A3DPQ3 (/IPI) O59010 (/IPI)
Amino acid:sodium symporter activity GO:0005283
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in).
 1 O59010 (/IDA)
Amino acid:sodium symporter activity GO:0005283
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in).
 1 O59010 (/IMP)
Chloride transmembrane transporter activity GO:0015108
Enables the transfer of chloride ions from one side of a membrane to the other.
 1 O59010 (/IDA)
L-aspartate transmembrane transporter activity GO:0015183
Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid.
 1 O59010 (/IMP)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-aspartate transmembrane transport GO:0070778
The directed movement of L-aspartate across a membrane.
 132 O59010 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA)
(122 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
 131 P0A830 (/IEP) P0A830 (/IEP) P0A830 (/IEP) P0A830 (/IEP) P0A830 (/IEP) P0A830 (/IEP) P0A830 (/IEP) P0A830 (/IEP) P0A830 (/IEP) P0A830 (/IEP)
(121 more)
Fumarate transport GO:0015741
The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
 131 P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA)
(121 more)
Fumarate transport GO:0015741
The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
 131 P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP) P0A830 (/IMP)
(121 more)
L-glutamate transmembrane transport GO:0015813
The directed movement of L-glutamate across a membrane.
 29 A0A0F7RKN8 (/ISS) A0A0F7RKN8 (/ISS) A0A0F7RLL2 (/ISS) A0A0F7RLL2 (/ISS) A0A0F7RLL2 (/ISS) A0A0F7RLL2 (/ISS) A0A0F7RLL2 (/ISS) A0A1J9UYS5 (/ISS) A0A1J9UYS5 (/ISS) A0A1J9UYS5 (/ISS)
(19 more)
Dicarboxylic acid transport GO:0006835
The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
 12 P21345 (/IMP) P21345 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP)
(2 more)
C4-dicarboxylate transport GO:0015740
The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.
 10 Q9I4F5 (/IDA) Q9I4F5 (/IDA) Q9I4F5 (/IDA) Q9I4F5 (/IDA) Q9I4F5 (/IDA) Q9I4F5 (/IDA) Q9I4F5 (/IDA) Q9I4F5 (/IDA) Q9I4F5 (/IDA) Q9I4F5 (/IDA)
C4-dicarboxylate transport GO:0015740
The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.
 10 Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP) Q9I4F5 (/IMP)
Protein homotrimerization GO:0070207
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
 1 O59010 (/IDA)
L-aspartate import across plasma membrane GO:0140009
The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol.
 1 O59010 (/IMP)
Chloride transmembrane transport GO:1902476
The process in which chloride is transported across a membrane.
 1 O59010 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 133 P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA)
(123 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
 131 P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA)
(121 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
 131 P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA) P0A830 (/IDA)
(121 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
 10 P71906 (/HDA) P71906 (/HDA) P71906 (/HDA) P71906 (/HDA) P71906 (/HDA) P71906 (/HDA) P71906 (/HDA) P71906 (/HDA) P71906 (/HDA) P71906 (/HDA)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 6 Q88RJ2 (/IDA) Q88RJ2 (/IDA) Q88RJ2 (/IDA) Q88RJ2 (/IDA) Q88RJ2 (/IDA) Q88RJ2 (/IDA)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 6 Q88RJ2 (/IPI) Q88RJ2 (/IPI) Q88RJ2 (/IPI) Q88RJ2 (/IPI) Q88RJ2 (/IPI) Q88RJ2 (/IPI)
CATH-Gene3D is a Global Biodata Core Resource Learn more...