The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 128: Two-pore potassium channel 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inward rectifier potassium channel activity GO:0005242
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
6 Q850M0 (/IDA) Q850M0 (/IDA) Q850M0 (/IDA) Q850M0 (/IDA) Q8LIN5 (/IDA) Q8LIN5 (/IDA)
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
2 Q8LBL1 (/IDA) Q8LBL1 (/IDA)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular potassium ion homeostasis GO:0030007
Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
6 Q850M0 (/IC) Q850M0 (/IC) Q850M0 (/IC) Q850M0 (/IC) Q8LIN5 (/IC) Q8LIN5 (/IC)
Regulation of seed germination GO:0010029
Any process that modulates the frequency, rate or extent of seed germination.
2 Q8LBL1 (/IMP) Q8LBL1 (/IMP)
Regulation of stomatal movement GO:0010119
Any process that modulates the frequency, rate or extent of stomatal movement.
2 Q8LBL1 (/IMP) Q8LBL1 (/IMP)
Cellular potassium ion homeostasis GO:0030007
Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
2 Q8LBL1 (/IMP) Q8LBL1 (/IMP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 Q8LBL1 (/IPI) Q8LBL1 (/IPI)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
2 Q8LIN5 (/IDA) Q8LIN5 (/IDA)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plant-type vacuole membrane GO:0009705
The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana.
6 Q850M0 (/IDA) Q850M0 (/IDA) Q850M0 (/IDA) Q850M0 (/IDA) Q8LIN5 (/IDA) Q8LIN5 (/IDA)
Potassium ion-transporting ATPase complex GO:0031004
Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex.
4 Q850M0 (/IDA) Q850M0 (/IDA) Q850M0 (/IDA) Q850M0 (/IDA)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
2 Q8LBL1 (/IDA) Q8LBL1 (/IDA)
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