The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Helix hairpin bin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: DNA polymerase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 30 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
DNA-directed DNA polymerase activity GO:0003887
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
9 C7IVS4 (/ISS) O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS) Q9NAH1 (/ISS)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
DNA-directed DNA polymerase activity GO:0003887
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
4 O89042 (/IDA) P09884 (/IDA) P33609 (/IDA) Q59J86 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P09884 (/IPI) P33609 (/IPI) Q9DE46 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P09884 (/NAS) Q59J86 (/NAS)
DNA-directed DNA polymerase activity GO:0003887
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
2 O89042 (/IMP) P09884 (/IMP)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
1 P09884 (/IDA)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
1 P33609 (/ISO)
Showing 1 to 10 of 30 entries

There are 42 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
9 C7IVS4 (/ISS) O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS) Q9NAH1 (/ISS)
DNA replication, synthesis of RNA primer GO:0006269
The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
DNA replication initiation GO:0006270
The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
DNA strand elongation involved in DNA replication GO:0006271
The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
Leading strand elongation GO:0006272
The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
Lagging strand elongation GO:0006273
The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
Double-strand break repair via nonhomologous end joining GO:0006303
The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
3 O89042 (/IMP) P09884 (/IMP) P33609 (/IMP)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
2 P33609 (/IDA) Q59J86 (/IDA)
Showing 1 to 10 of 42 entries

There are 26 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 C7IVS4 (/ISS) O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS) Q9NAH1 (/ISS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
Alpha DNA polymerase:primase complex GO:0005658
A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
7 O89042 (/ISS) P33609 (/ISS) Q59J86 (/ISS) Q59J88 (/ISS) Q59J89 (/ISS) Q59J90 (/ISS) Q9DE46 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P09884 (/IDA) P33609 (/IDA) Q57UW4 (/IDA) Q59J86 (/IDA)
Alpha DNA polymerase:primase complex GO:0005658
A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.
4 O89042 (/IDA) P09884 (/IDA) P33609 (/IDA) Q59J86 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 A0A087WU64 (/IDA) A6NMQ1 (/IDA) P09884 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 A0A087WU64 (/IDA) A6NMQ1 (/IDA) P09884 (/IDA)
Showing 1 to 10 of 26 entries
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