The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Serine-tRNA synthetase, tRNA binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Serine--tRNA ligase, cytoplasmic

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
10 P13642 (/ISS) P26636 (/ISS) P26636 (/ISS) P26638 (/ISS) Q4R4U9 (/ISS) Q5R9K9 (/ISS) Q5R9K9 (/ISS) Q6DRC0 (/ISS) Q6P799 (/ISS) Q9GMB8 (/ISS)
Serine-tRNA ligase activity GO:0004828
Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
10 P13642 (/ISS) P26636 (/ISS) P26636 (/ISS) P26638 (/ISS) Q4R4U9 (/ISS) Q5R9K9 (/ISS) Q5R9K9 (/ISS) Q6DRC0 (/ISS) Q6P799 (/ISS) Q9GMB8 (/ISS)
Serine-tRNA ligase activity GO:0004828
Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
2 P49591 (/IDA) Q6DRC0 (/IDA)
Serine-tRNA ligase activity GO:0004828
Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
2 P49591 (/TAS) Q9VQL1 (/TAS)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 P49591 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 P26638 (/ISO)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P49591 (/TAS)
Serine-tRNA ligase activity GO:0004828
Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).
1 P26638 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P49591 (/IPI)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q9VQL1 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P49591 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P26638 (/ISO)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
10 P13642 (/ISS) P26636 (/ISS) P26636 (/ISS) P26638 (/ISS) Q4R4U9 (/ISS) Q5R9K9 (/ISS) Q5R9K9 (/ISS) Q6DRC0 (/ISS) Q6P799 (/ISS) Q9GMB8 (/ISS)
Seryl-tRNA aminoacylation GO:0006434
The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.
10 P13642 (/ISS) P26636 (/ISS) P26636 (/ISS) P26638 (/ISS) Q4R4U9 (/ISS) Q5R9K9 (/ISS) Q5R9K9 (/ISS) Q6DRC0 (/ISS) Q6P799 (/ISS) Q9GMB8 (/ISS)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
10 P13642 (/ISS) P26636 (/ISS) P26636 (/ISS) P26638 (/ISS) Q4R4U9 (/ISS) Q5R9K9 (/ISS) Q5R9K9 (/ISS) Q6DRC0 (/ISS) Q6P799 (/ISS) Q9GMB8 (/ISS)
Negative regulation of vascular endothelial growth factor production GO:1904046
Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production.
9 P13642 (/ISS) P26636 (/ISS) P26636 (/ISS) P26638 (/ISS) Q4R4U9 (/ISS) Q5R9K9 (/ISS) Q5R9K9 (/ISS) Q6P799 (/ISS) Q9GMB8 (/ISS)
Seryl-tRNA aminoacylation GO:0006434
The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.
2 P49591 (/IDA) Q6DRC0 (/IDA)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
2 P49591 (/IMP) Q6DRC0 (/IMP)
Negative regulation of vascular endothelial growth factor production GO:1904046
Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production.
2 P49591 (/IDA) Q6DRC0 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P49591 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q18678 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P26638 (/ISO)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 Q6DRC0 (/IMP)
Branching involved in blood vessel morphogenesis GO:0001569
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
1 Q6DRC0 (/IMP)
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
1 Q6DRC0 (/IMP)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
1 Q18678 (/IMP)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
1 P49591 (/TAS)
TRNA aminoacylation for protein translation GO:0006418
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.
1 P49591 (/TAS)
Seryl-tRNA aminoacylation GO:0006434
The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.
1 P49591 (/IMP)
Seryl-tRNA aminoacylation GO:0006434
The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.
1 P26638 (/ISO)
Seryl-tRNA aminoacylation GO:0006434
The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.
1 Q9VQL1 (/TAS)
TRNA processing GO:0008033
The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
1 P49591 (/TAS)
Selenocysteine metabolic process GO:0016259
The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins.
1 P49591 (/TAS)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
1 P26638 (/ISO)
Cerebellum vasculature development GO:0061300
The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure.
1 Q6DRC0 (/IMP)
Regulation of vasculature development GO:1901342
Any process that modulates the frequency, rate or extent of vasculature development.
1 Q6DRC0 (/IGI)
Negative regulation of sprouting angiogenesis GO:1903671
Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis.
1 Q6DRC0 (/IMP)
Negative regulation of vascular endothelial growth factor production GO:1904046
Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production.
1 Q6DRC0 (/IMP)
Negative regulation of vascular endothelial growth factor production GO:1904046
Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production.
1 P26638 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 P13642 (/ISS) P26636 (/ISS) P26636 (/ISS) Q4R4U9 (/ISS) Q5R9K9 (/ISS) Q5R9K9 (/ISS) Q6P799 (/ISS) Q9GMB8 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P49591 (/IDA) Q5T5C7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6DRC0 (/IMP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P49591 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P26638 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9VQL1 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P26638 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P26638 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P49591 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P49591 (/HDA)
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