The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: DNA-directed RNA polymerase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-directed 5'-3' RNA polymerase activity GO:0003899
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
5 O00411 (/IDA) P13433 (/IDA) P13433 (/IDA) P13433 (/IDA) Q95NZ8 (/IDA)
Mitochondrial single subunit type RNA polymerase activity GO:0001065
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
4 Q385J0 (/IMP) Q385J0 (/IMP) Q385J0 (/IMP) Q95WT2 (/IMP)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
4 Q385J0 (/ISM) Q385J0 (/ISM) Q385J0 (/ISM) Q95WT2 (/ISM)
DNA-directed 5'-3' RNA polymerase activity GO:0003899
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
4 Q385J0 (/ISM) Q385J0 (/ISM) Q385J0 (/ISM) Q95WT2 (/ISM)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O00411 (/IPI) O24600 (/IPI) Q8BKF1 (/IPI) Q8BKF1 (/IPI)
DNA primase activity GO:0003896
Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases.
3 P13433 (/IDA) P13433 (/IDA) P13433 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 O00411 (/IDA) Q8BKF1 (/IDA) Q8BKF1 (/IDA)
DNA-directed 5'-3' RNA polymerase activity GO:0003899
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
2 Q8BKF1 (/ISO) Q8BKF1 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q8BKF1 (/ISO) Q8BKF1 (/ISO)
Mitochondrial promoter sequence-specific DNA binding GO:0001018
Interacting selectively and non-covalently with a DNA region that controls the transcription of the mitochondrial DNA.
1 O13993 (/IDA)
Mitochondrial single subunit type RNA polymerase activity GO:0001065
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
1 Q4QAL7 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q95NZ8 (/IC)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 O00411 (/HDA)
DNA-directed 5'-3' RNA polymerase activity GO:0003899
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
1 Q9VPW4 (/ISS)
DNA-directed 5'-3' RNA polymerase activity GO:0003899
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
1 O00411 (/TAS)
5'-3' RNA polymerase activity GO:0034062
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end.
1 F4KB75 (/TAS)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial transcription GO:0006390
The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.
8 O13993 (/IMP) P13433 (/IMP) P13433 (/IMP) P13433 (/IMP) Q385J0 (/IMP) Q385J0 (/IMP) Q385J0 (/IMP) Q95WT2 (/IMP)
Mitochondrial transcription GO:0006390
The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.
5 O00411 (/IDA) P13433 (/IDA) P13433 (/IDA) P13433 (/IDA) Q95NZ8 (/IDA)
Mitochondrial DNA replication GO:0006264
The process in which new strands of DNA are synthesized in the mitochondrion.
4 Q385J0 (/IMP) Q385J0 (/IMP) Q385J0 (/IMP) Q95WT2 (/IMP)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
4 Q385J0 (/ISM) Q385J0 (/ISM) Q385J0 (/ISM) Q95WT2 (/ISM)
Mitochondrial genome maintenance GO:0000002
The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
3 P13433 (/IMP) P13433 (/IMP) P13433 (/IMP)
DNA replication, synthesis of RNA primer GO:0006269
The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis.
3 P13433 (/IDA) P13433 (/IDA) P13433 (/IDA)
Mitochondrial transcription GO:0006390
The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.
3 Q4QAL7 (/ISO) Q8BKF1 (/ISO) Q8BKF1 (/ISO)
Mitochondrial DNA replication GO:0006264
The process in which new strands of DNA are synthesized in the mitochondrion.
1 Q4QAL7 (/ISO)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 Q9VPW4 (/ISS)
Mitochondrial transcription GO:0006390
The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.
1 O00411 (/TAS)
Transcription initiation from mitochondrial promoter GO:0006391
A transcription initiation process that takes place at a promoter on the mitochondrial chromosome, and results in RNA synthesis by a mitochondrial RNA polymerase.
1 O00411 (/TAS)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 O00411 (/TAS)
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
1 F4I0I3 (/IMP)
Pollen tube growth GO:0009860
Growth of pollen via tip extension of the intine wall.
1 F4I0I3 (/IMP)
Plant ovule development GO:0048481
The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed.
1 F4I0I3 (/IMP)

There are 24 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 O00411 (/IDA) O13993 (/IDA) O24600 (/IDA) Q8VWF8 (/IDA) Q8VWF8 (/IDA) Q93Y94 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 P13433 (/HDA) P13433 (/HDA) P13433 (/HDA) Q8BKF1 (/HDA) Q8BKF1 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 O13993 (/HDA) P13433 (/HDA) P13433 (/HDA) P13433 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q385J0 (/IDA) Q385J0 (/IDA) Q385J0 (/IDA) Q95WT2 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 Q385J0 (/RCA) Q385J0 (/RCA) Q385J0 (/RCA) Q95WT2 (/RCA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
4 O00411 (/IDA) P13433 (/IDA) P13433 (/IDA) P13433 (/IDA)
Plastid GO:0009536
Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
4 P69242 (/IDA) P69242 (/IDA) Q8VWF8 (/IDA) Q8VWF8 (/IDA)
Mitochondrial DNA-directed RNA polymerase complex GO:0034245
A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form.
4 O13993 (/IDA) P13433 (/IDA) P13433 (/IDA) P13433 (/IDA)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
4 O00411 (/IDA) P13433 (/IDA) P13433 (/IDA) P13433 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
4 Q385J0 (/IDA) Q385J0 (/IDA) Q385J0 (/IDA) Q95WT2 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 O00411 (/IDA) Q8BKF1 (/IDA) Q8BKF1 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q8BKF1 (/ISO) Q8BKF1 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 Q8BKF1 (/ISO) Q8BKF1 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 O13993 (/ISS) Q95NZ8 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 Q8BKF1 (/ISO) Q8BKF1 (/ISO)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
2 Q8BKF1 (/ISO) Q8BKF1 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q4QAL7 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9VPW4 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 F4KB75 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 O00411 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O13993 (/HDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 F4KB75 (/TAS)
Thylakoid membrane GO:0042651
The pigmented membrane of any thylakoid.
1 F4KB75 (/TAS)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 Q4QAL7 (/ISO)
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