CATH Superfamily 1.10.287.130
Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 3: Histidine kinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
|
115 |
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
(105 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
115 |
P0AEC5 (/IPI)
P0AEC5 (/IPI)
P0AEC5 (/IPI)
P0AEC5 (/IPI)
P0AEC5 (/IPI)
P0AEC5 (/IPI)
P0AEC5 (/IPI)
P0AEC5 (/IPI)
P0AEC5 (/IPI)
P0AEC5 (/IPI)
(105 more) |
|
Histidine phosphotransfer kinase activity GO:0009927
Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator.
|
115 |
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
(105 more) |
|
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
|
6 | Q9KPC0 (/ISS) Q9KPC0 (/ISS) Q9KPC0 (/ISS) Q9KPC0 (/ISS) Q9KPC0 (/ISS) Q9KPC0 (/ISS) |
|
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
|
6 | Q9KPC0 (/ISS) Q9KPC0 (/ISS) Q9KPC0 (/ISS) Q9KPC0 (/ISS) Q9KPC0 (/ISS) Q9KPC0 (/ISS) |
|
Phosphorelay sensor kinase activity GO:0000155
Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
|
1 | Q54U87 (/IMP) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q54U87 (/TAS) |
|
Transmembrane receptor histidine kinase activity GO:0009784
Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate.
|
1 | Q54U87 (/IGI) |
There are 17 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
|
115 |
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
(105 more) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
115 |
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
(105 more) |
|
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
115 |
P0AEC5 (/IMP)
P0AEC5 (/IMP)
P0AEC5 (/IMP)
P0AEC5 (/IMP)
P0AEC5 (/IMP)
P0AEC5 (/IMP)
P0AEC5 (/IMP)
P0AEC5 (/IMP)
P0AEC5 (/IMP)
P0AEC5 (/IMP)
(105 more) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
115 |
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
(105 more) |
|
Cellular response to organic substance GO:0071310
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
|
115 |
P0AEC5 (/IEP)
P0AEC5 (/IEP)
P0AEC5 (/IEP)
P0AEC5 (/IEP)
P0AEC5 (/IEP)
P0AEC5 (/IEP)
P0AEC5 (/IEP)
P0AEC5 (/IEP)
P0AEC5 (/IEP)
P0AEC5 (/IEP)
(105 more) |
|
Positive regulation of secondary metabolite biosynthetic process GO:1900378
Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.
|
16 |
G3XD98 (/IMP)
G3XD98 (/IMP)
G3XD98 (/IMP)
G3XD98 (/IMP)
G3XD98 (/IMP)
G3XD98 (/IMP)
G3XD98 (/IMP)
G3XD98 (/IMP)
O31138 (/IMP)
O31138 (/IMP)
(6 more) |
|
Positive regulation of cell motility GO:2000147
Any process that activates or increases the frequency, rate or extent of cell motility.
|
16 |
G3XD98 (/IMP)
G3XD98 (/IMP)
G3XD98 (/IMP)
G3XD98 (/IMP)
G3XD98 (/IMP)
G3XD98 (/IMP)
G3XD98 (/IMP)
G3XD98 (/IMP)
O31138 (/IMP)
O31138 (/IMP)
(6 more) |
|
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
|
6 | Q9KPC0 (/ISS) Q9KPC0 (/ISS) Q9KPC0 (/ISS) Q9KPC0 (/ISS) Q9KPC0 (/ISS) Q9KPC0 (/ISS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | Q54U87 (/IGI) |
|
CAMP-mediated signaling GO:0019933
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
|
1 | Q54U87 (/IMP) |
|
Sporulation resulting in formation of a cellular spore GO:0030435
The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.
|
1 | Q54U87 (/IMP) |
|
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
|
1 | Q54U87 (/HMP) |
|
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
|
1 | Q54U87 (/IMP) |
|
Sorocarp stalk development GO:0031150
The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum.
|
1 | Q54U87 (/IMP) |
|
Sorocarp morphogenesis GO:0031288
The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum.
|
1 | Q54U87 (/IGI) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
1 | Q54U87 (/IMP) |
|
Negative regulation of cyclic-nucleotide phosphodiesterase activity GO:0051344
Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
|
1 | Q54U87 (/TAS) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
115 |
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
P0AEC5 (/IDA)
(105 more) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q54U87 (/IDA) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | Q54U87 (/IDA) |
|
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | Q54U87 (/IDA) |
