The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"S15/NS1, RNA-binding
".
FunFam 14: Methionyl-tRNA synthetase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Methionine-tRNA ligase activity GO:0004825
Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
|
6 | A1ZBE9 (/ISS) A1ZBE9 (/ISS) A1ZBE9 (/ISS) Q8MRS4 (/ISS) Q8MRS4 (/ISS) Q8MRS4 (/ISS) |
|
Methionine-tRNA ligase activity GO:0004825
Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
|
6 | A1ZBE9 (/TAS) A1ZBE9 (/TAS) A1ZBE9 (/TAS) Q8MRS4 (/TAS) Q8MRS4 (/TAS) Q8MRS4 (/TAS) |
|
Histidine-tRNA ligase activity GO:0004821
Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).
|
1 | O43011 (/ISS) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | O43011 (/ISM) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Methionyl-tRNA aminoacylation GO:0006431
The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
|
6 | A1ZBE9 (/ISS) A1ZBE9 (/ISS) A1ZBE9 (/ISS) Q8MRS4 (/ISS) Q8MRS4 (/ISS) Q8MRS4 (/ISS) |
|
Methionyl-tRNA aminoacylation GO:0006431
The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
|
6 | A1ZBE9 (/TAS) A1ZBE9 (/TAS) A1ZBE9 (/TAS) Q8MRS4 (/TAS) Q8MRS4 (/TAS) Q8MRS4 (/TAS) |
|
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
|
1 | O43011 (/ISO) |
|
Histidyl-tRNA aminoacylation GO:0006427
The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.
|
1 | O43011 (/ISS) |
|
Mitochondrial translation GO:0032543
The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
|
1 | O43011 (/ISO) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | A1ZBE9 (/TAS) A1ZBE9 (/TAS) A1ZBE9 (/TAS) Q8MRS4 (/TAS) Q8MRS4 (/TAS) Q8MRS4 (/TAS) |
|
Aminoacyl-tRNA synthetase multienzyme complex GO:0017101
A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
|
6 | A1ZBE9 (/IDA) A1ZBE9 (/IDA) A1ZBE9 (/IDA) Q8MRS4 (/IDA) Q8MRS4 (/IDA) Q8MRS4 (/IDA) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | O43011 (/IC) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O43011 (/HDA) |
