The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: DNA repair helicase RAD3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
6 P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P06839 (/IPI) P06839 (/IPI) P06839 (/IPI) P06839 (/IPI) P06839 (/IPI) P06839 (/IPI)
5'-3' DNA helicase activity GO:0043139
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'.
6 P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA)
5'-3' DNA helicase activity GO:0043139
Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'.
6 P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP)
4 iron, 4 sulfur cluster binding GO:0051539
Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
6 P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of mitotic recombination GO:0000019
Any process that modulates the frequency, rate or extent of DNA recombination during mitosis.
6 P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
6 P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA)
Regulation of transposition, RNA-mediated GO:0010525
Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate.
6 P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP)
Nucleotide-excision repair, DNA incision GO:0033683
A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound.
6 P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA)
Positive regulation of mitotic recombination GO:0045951
Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis.
6 P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP) P06839 (/IMP)
Phosphorylation of RNA polymerase II C-terminal domain GO:0070816
The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.
6 P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleotide-excision repair factor 3 complex GO:0000112
One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p).
6 P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA)
Transcription factor TFIIH core complex GO:0000439
The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD.
6 P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA)
Transcription factor TFIIH holo complex GO:0005675
A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.
6 P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA) P06839 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P06839 (/TAS) P06839 (/TAS) P06839 (/TAS) P06839 (/TAS) P06839 (/TAS) P06839 (/TAS)
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