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CATH Superfamily 1.10.260.40

lambda repressor-like DNA-binding domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
lambda repressor-like DNA-binding domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Transcriptional regulator SinRTranscriptional regulatorSC:2DNA-binding transcriptional regulator SfsBLexA family transcriptional repressorSC:3Fructose repressor (Catabolite repressor/activator)HTH-type transcriptional regulator GntRSC:4DNA-binding protein SATBCut-like homeobox 1aCut-like homeobox 1aPOU domain proteinSC:5Endothelial differentiation-related factor 1SC:6POU domain proteinTranscriptional Regulator BldDPOU domain proteinCyanate hydrataseHTH-type transcriptional regulator hipBAntitoxin HigA(S)-2-hydroxypropylphosphonic acid epoxidaseSC:7Secretion protein EspRHTH-type transcriptional repressor PurROne cut domain family memberHepatocyte nuclear factor 1-betahomeobox-containing protein 1 isoform X2Cytoskeleton protein RodZHTH-type transcriptional regulator PuuRMultiprotein bridging factor 1Maltose regulon transcriptional regulator MalITrifunctional nicotinamide-nucleotide adenylyltransferase/ribosylnicotinamide kinase/transcriptional regulator NadRTrehalose operon repressorPOU domain proteinCro/Cl family transcriptional regulatorPredicted DNA-binding transcriptional regulatorHomeobox protein cut-likeXRE family transcriptional regulatorCoactivator bridging factor 1DNA-binding transcriptional repressor EbgRTranscriptional regulator ClgRAnsR family transcriptional regulatorAntitoxin MqsALacI family transcriptional regulatorType II toxin-antitoxin system HigA family antitoxinLacI family transcriptional regulatorPOU domain, class 6, transcription factor 2Asc operon transcriptional repressorLacI family transcriptional regulatorDNA-binding proteinHomeobox domain-containing proteinSWI/SNF-related matrix-associated actin-dependent regulator of chromatin, putativeCyanate hydrataseOne cut domain family memberDNA-binding helix-turn-helix proteinXRE family transcriptional regulatorHTH-type transcriptional regulatorProbable transcriptional regulatorHTH-type transcriptional regulator DicATranscriptional regulatorPOU domain proteinXRE family transcriptional regulatorTranscriptional regulatorXRE family transcriptional regulatorMultiprotein-bridging factor 1LacI family DNA-binding transcriptional regulatorDNA transposition protein (GpB)Predicted transcriptional regulatorHTH-type transcriptional regulator prtRTranscriptional repressor RstRHomeobox protein cut-likeShikimate kinaseUncharacterized proteinTranscriptional regulatorAddiction module antidote protein, HigA familyOne cut domain family member 2Helix-turn-helix transcriptional regulator, XRE familytranscription factor proteinHomeobox protein cut-likeResponse regulator receiverPeptidase M23Replication factor C small subunitHelix-turn-helix domain proteinVirulence-associated protein ITranscriptional regulator of HTH-type, xre familyHelix-turn-helix XRE domain proteinTranscriptional repressor LexA, putativePhage repressor-like proteinUncharacterized proteinTranscription factor proteinGlutamine--fructose-6-phosphate aminotransferase [isomerizing]Mu phage transposase OrfB TnpB_MuSo2Homeodomain-containing DNA- binding protein, putative2-hydroxyethylphosphonate dioxygenaseUncharacterized proteinHipB protein, putativePou4f2Transcriptional regulator, putativeMBF1 transcription factorUncharacterized proteinOctamer-binding transcription factor 3Uncharacterized proteinPredicted transcriptional regulator, XRE familyUncharacterized proteinRepressor protein cI
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FunFam 59: Transcriptional regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 11 Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA)
(1 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
 11 Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI)
(1 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 11 Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA)
(1 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
 11 Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI)
(1 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
 11 Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA)
(1 more)
Showing 1 to 5 of 5 entries

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 11 Q9I063 (/EXP) Q9I063 (/EXP) Q9I063 (/EXP) Q9I063 (/EXP) Q9I063 (/EXP) Q9I063 (/EXP) Q9I063 (/EXP) Q9I063 (/EXP) Q9I063 (/EXP) Q9I063 (/EXP)
(1 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 11 Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA)
(1 more)
Positive regulation of single-species biofilm formation GO:1900192
Any process that activates or increases the frequency, rate or extent of single-species biofilm formation.
 11 Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP)
(1 more)
Negative regulation of cell motility GO:2000146
Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.
 11 Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP) Q9I063 (/IMP)
(1 more)
Showing 1 to 4 of 4 entries

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 11 Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA) Q9I063 (/IDA)
(1 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 11 Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI) Q9I063 (/IPI)
(1 more)
Showing 1 to 2 of 2 entries
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