The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
SWIB/MDM2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Upstream activation factor subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA polymerase I upstream control element sequence-specific DNA binding GO:0001165
Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I.
6 Q08747 (/IDA) Q08747 (/IDA) Q08747 (/IDA) Q08747 (/IDA) Q08747 (/IDA) Q08747 (/IDA)
RNA polymerase I general transcription initiation factor activity GO:0001181
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3.
6 Q08747 (/IMP) Q08747 (/IMP) Q08747 (/IMP) Q08747 (/IMP) Q08747 (/IMP) Q08747 (/IMP)
RNA polymerase I general transcription initiation factor activity GO:0001181
An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3.
1 O74503 (/IC)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 O74503 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q22749 (/ISS)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
6 Q08747 (/IMP) Q08747 (/IMP) Q08747 (/IMP) Q08747 (/IMP) Q08747 (/IMP) Q08747 (/IMP)
Nucleolar large rRNA transcription by RNA polymerase I GO:0042790
The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.
6 Q08747 (/IMP) Q08747 (/IMP) Q08747 (/IMP) Q08747 (/IMP) Q08747 (/IMP) Q08747 (/IMP)
Mitochondrial DNA repair GO:0043504
The process of restoring mitochondrial DNA after damage.
2 Q9C504 (/IMP) Q9C504 (/IMP)
Mitochondrial double-strand break repair via homologous recombination GO:0097552
The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences.
2 Q9C504 (/IMP) Q9C504 (/IMP)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
1 Q22749 (/ISS)
Transcription initiation from RNA polymerase I promoter GO:0006361
Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
1 O74503 (/EXP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 O74503 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
8 Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA) Q05024 (/HDA)
RNA polymerase I upstream activating factor complex GO:0000500
A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p.
6 Q08747 (/IDA) Q08747 (/IDA) Q08747 (/IDA) Q08747 (/IDA) Q08747 (/IDA) Q08747 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
6 Q08747 (/IDA) Q08747 (/IDA) Q08747 (/IDA) Q08747 (/IDA) Q08747 (/IDA) Q08747 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
6 F4J9Z9 (/IDA) F4J9Z9 (/IDA) F4J9Z9 (/IDA) F4J9Z9 (/IDA) F4J9Z9 (/IDA) F4J9Z9 (/IDA)
RNA polymerase I upstream activating factor complex GO:0000500
A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p.
1 O74503 (/EXP)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q22749 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O74503 (/HDA)
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