The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 43: Kv channel-interacting protein 1 isoform 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 32 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
53 Q17QD9 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS)
(43 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
44 Q6PIL6 (/IPI) Q6PIL6 (/IPI) Q6PIL6 (/IPI) Q6PIL6 (/IPI) Q6PIL6 (/IPI) Q6PIL6 (/IPI) Q6PIL6 (/IPI) Q6PIL6 (/IPI) Q6PIL6 (/IPI) Q6PIL6 (/IPI)
(34 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
40 Q6PHZ8 (/IDA) Q6PHZ8 (/IDA) Q6PHZ8 (/IDA) Q6PHZ8 (/IDA) Q6PHZ8 (/IDA) Q6PHZ8 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA)
(30 more)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
27 Q8R426 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q9JM47 (/IDA) Q9JM59 (/IDA) Q9NS61 (/IDA)
(17 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
25 Q8HYN7 (/ISS) Q8HYN7 (/ISS) Q8HYN7 (/ISS) Q8HYN7 (/ISS) Q8HYN7 (/ISS) Q8HYN7 (/ISS) Q8HYN7 (/ISS) Q8HYN7 (/ISS) Q8HYN7 (/ISS) Q8HYN7 (/ISS)
(15 more)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
12 Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q9JJ57 (/ISO) Q9JJ57 (/ISO) Q9JJ57 (/ISO) Q9JJ69 (/ISO)
(2 more)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
10 Q6PHZ8 (/IMP) Q6PHZ8 (/IMP) Q6PHZ8 (/IMP) Q6PHZ8 (/IMP) Q6PHZ8 (/IMP) Q6PHZ8 (/IMP) Q9JJ69 (/IMP) Q9JM59 (/IMP) Q9QXT8 (/IMP) Q9QXT8 (/IMP)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
9 Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q9JJ57 (/ISO) Q9JJ57 (/ISO) Q9JJ57 (/ISO)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
6 Q9JJ57 (/ISO) Q9JJ57 (/ISO) Q9JJ57 (/ISO) Q9JJ69 (/ISO) Q9QXT8 (/ISO) Q9QXT8 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 Q9NS61 (/TAS) Q9NS61 (/TAS) Q9Y2W7 (/TAS) Q9Y2W7 (/TAS)
Showing 1 to 10 of 32 entries

There are 39 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Regulation of potassium ion transmembrane transport GO:1901379
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.
58 Q17QD9 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS)
(48 more)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
42 Q17QD9 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS)
(32 more)
Cardiac conduction GO:0061337
Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.
36 Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS)
(26 more)
Regulation of potassium ion transmembrane transport GO:1901379
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.
25 Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q9JM59 (/IDA) Q9NS61 (/IDA) Q9NS61 (/IDA) Q9NZI2 (/IDA)
(15 more)
Regulation of potassium ion transmembrane transport GO:1901379
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.
10 Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q9JJ57 (/ISO) Q9JJ57 (/ISO) Q9JJ57 (/ISO) Q9JJ69 (/ISO)
Regulation of potassium ion transmembrane transport GO:1901379
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.
9 Q6PHZ8 (/IMP) Q6PHZ8 (/IMP) Q6PHZ8 (/IMP) Q6PHZ8 (/IMP) Q6PHZ8 (/IMP) Q6PHZ8 (/IMP) Q9JJ69 (/IMP) Q9QXT8 (/IMP) Q9QXT8 (/IMP)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
8 Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q9QXT8 (/IDA) Q9QXT8 (/IDA)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
6 A0A0R4IBJ8 (/IMP) A0A2R8QMM6 (/IMP) A7MCK1 (/IMP) A7MCK1 (/IMP) E7FDK3 (/IMP) Q6PBP8 (/IMP)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
6 Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 Q9NS61 (/TAS) Q9NS61 (/TAS) Q9QXT8 (/TAS) Q9QXT8 (/TAS)
Showing 1 to 10 of 39 entries

There are 35 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
51 Q17QD9 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS)
(41 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
46 Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS)
(36 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
42 Q17QD9 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PHZ8 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS) Q6PIL6 (/ISS)
(32 more)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
37 Q6PHZ8 (/IDA) Q6PHZ8 (/IDA) Q6PHZ8 (/IDA) Q6PHZ8 (/IDA) Q6PHZ8 (/IDA) Q6PHZ8 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA) Q99MG9 (/IDA)
(27 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
36 Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS) Q6PIL6 (/TAS)
(26 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
34 Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA)
(24 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
24 Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA) Q6PIL6 (/IDA)
(14 more)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
16 Q9NZI2 (/IDA) Q9NZI2 (/IDA) Q9NZI2 (/IDA) Q9NZI2 (/IDA) Q9NZI2 (/IDA) Q9NZI2 (/IDA) Q9NZI2 (/IDA) Q9NZI2 (/IDA) Q9NZI2 (/IDA) Q9NZI2 (/IDA)
(6 more)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
11 Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q9JJ57 (/ISO) Q9JJ57 (/ISO) Q9JJ57 (/ISO) Q9QXT8 (/ISO)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q6PHZ8 (/ISO) Q9JJ57 (/ISO) Q9JJ57 (/ISO) Q9JJ57 (/ISO) Q9JJ69 (/ISO)
Showing 1 to 10 of 35 entries
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