The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450-Terp, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Citrate synthase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
2-methylcitrate synthase activity GO:0050440
Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+).
69 H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA)
(59 more)
Citrate synthase activity GO:0036440
Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
56 H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA)
(46 more)
Citrate synthase activity GO:0036440
Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
31 I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS)
(21 more)
2-methylcitrate synthase activity GO:0050440
Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+).
30 I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS)
(20 more)
Citrate (Si)-synthase activity GO:0004108
Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.
20 P31660 (/IDA) P31660 (/IDA) P31660 (/IDA) P31660 (/IDA) P31660 (/IDA) P31660 (/IDA) P31660 (/IDA) P31660 (/IDA) P31660 (/IDA) P31660 (/IDA)
(10 more)
Citrate (Si)-synthase activity GO:0004108
Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.
20 P31660 (/IGI) P31660 (/IGI) P31660 (/IGI) P31660 (/IGI) P31660 (/IGI) P31660 (/IGI) P31660 (/IGI) P31660 (/IGI) P31660 (/IGI) P31660 (/IGI)
(10 more)
Citrate (Si)-synthase activity GO:0004108
Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.
13 A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS)
(3 more)
2-methylcitrate synthase activity GO:0050440
Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+).
13 O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP)
(3 more)
Oxo-acid-lyase activity GO:0016833
Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid.
11 Q83DG4 (/ISS) Q883R2 (/ISS) Q883R2 (/ISS) Q883R2 (/ISS) Q8EJW2 (/ISS) Q9KSC1 (/ISS) Q9KSC1 (/ISS) Q9KSC1 (/ISS) Q9KSC1 (/ISS) Q9KSC1 (/ISS)
(1 more)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Propionate metabolic process, methylcitrate cycle GO:0019679
The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.
67 H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA) H8F0D7 (/IDA)
(57 more)
Propionate metabolic process, methylcitrate cycle GO:0019679
The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.
30 I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS) I6Y9Q3 (/ISS)
(20 more)
Propionate metabolic process, methylcitrate cycle GO:0019679
The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.
26 I6Y9Q3 (/IMP) I6Y9Q3 (/IMP) I6Y9Q3 (/IMP) I6Y9Q3 (/IMP) I6Y9Q3 (/IMP) I6Y9Q3 (/IMP) I6Y9Q3 (/IMP) I6Y9Q3 (/IMP) I6Y9Q3 (/IMP) I6Y9Q3 (/IMP)
(16 more)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
13 A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS) A0A2B6C8U7 (/ISS)
(3 more)
Response to acidic pH GO:0010447
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
13 O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP)
(3 more)
Propionate catabolic process, 2-methylcitrate cycle GO:0019629
The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.
13 O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP) O08395 (/IMP)
(3 more)
Response to host immune response GO:0052572
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
13 O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP) O08395 (/IEP)
(3 more)
Fermentation GO:0006113
The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP).
10 Q883R2 (/ISS) Q883R2 (/ISS) Q883R2 (/ISS) Q8EJW2 (/ISS) Q9KSC1 (/ISS) Q9KSC1 (/ISS) Q9KSC1 (/ISS) Q9KSC1 (/ISS) Q9KSC1 (/ISS) Q9KSC1 (/ISS)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
8 Q9I5E3 (/IDA) Q9I5E3 (/IDA) Q9I5E3 (/IDA) Q9I5E3 (/IDA) Q9I5E3 (/IDA) Q9I5E3 (/IDA) Q9I5E3 (/IDA) Q9I5E3 (/IDA)
Asexual sporulation GO:0030436
The formation of spores derived from the products of an asexual cell division. Examples of this process are found in bacteria and fungi.
2 Q81KZ5 (/ISS) Q81KZ5 (/ISS)
Propionate catabolic process, 2-methylcitrate cycle GO:0019629
The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.
1 Q83DG4 (/ISS)
Propionate metabolic process, methylcitrate cycle GO:0019679
The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.
1 Q8EJW2 (/TAS)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tricarboxylic acid cycle enzyme complex GO:0045239
Any of the heteromeric enzymes that act in the TCA cycle.
8 Q9I5E3 (/IDA) Q9I5E3 (/IDA) Q9I5E3 (/IDA) Q9I5E3 (/IDA) Q9I5E3 (/IDA) Q9I5E3 (/IDA) Q9I5E3 (/IDA) Q9I5E3 (/IDA)
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