The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Annexin
".
FunFam 62: Annexin A1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | P24551 (/ISS) |
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
|
1 | P24551 (/ISS) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Monocyte chemotaxis GO:0002548
The movement of a monocyte in response to an external stimulus.
|
1 | P24551 (/ISS) |
Regulation of leukocyte migration GO:0002685
Any process that modulates the frequency, rate, or extent of leukocyte migration.
|
1 | P24551 (/ISS) |
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
|
1 | P24551 (/ISS) |
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | P24551 (/ISS) |
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
|
1 | P24551 (/ISS) |
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
1 | P24551 (/ISS) |
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | P24551 (/ISS) |
Regulation of interleukin-1 production GO:0032652
Any process that modulates the frequency, rate, or extent of interleukin-1 production.
|
1 | P24551 (/ISS) |
Positive regulation of interleukin-2 production GO:0032743
Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
|
1 | P24551 (/ISS) |
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
|
1 | P24551 (/ISS) |
Positive regulation of T-helper 1 cell differentiation GO:0045627
Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation.
|
1 | P24551 (/ISS) |
Negative regulation of T-helper 2 cell differentiation GO:0045629
Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.
|
1 | P24551 (/ISS) |
Negative regulation of exocytosis GO:0045920
Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
|
1 | P24551 (/ISS) |
Regulation of hormone secretion GO:0046883
Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.
|
1 | P24551 (/ISS) |
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
|
1 | P24551 (/ISS) |
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
|
1 | P24551 (/ISS) |
Granulocyte chemotaxis GO:0071621
The movement of a granulocyte in response to an external stimulus.
|
1 | P24551 (/ISS) |
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
|
1 | P24551 (/ISS) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P24551 (/ISS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P24551 (/ISS) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | P24551 (/ISS) |
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
|
1 | P24551 (/ISS) |
Extrinsic component of external side of plasma membrane GO:0031232
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.
|
1 | P24551 (/ISS) |
Extrinsic component of endosome membrane GO:0031313
The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
1 | P24551 (/ISS) |
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
|
1 | P24551 (/ISS) |
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
1 | P24551 (/ISS) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P24551 (/ISS) |