The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Frizzled cysteine-rich domain
".
FunFam 10: Smoothened, frizzled class receptor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P56726 (/IPI) P56726 (/IPI) Q99835 (/IPI) |
|
Oxysterol binding GO:0008142
Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol.
|
3 | Q5RH73 (/IDA) Q90X26 (/IDA) Q90YY4 (/IDA) |
|
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
|
3 | P56726 (/IDA) P56726 (/IDA) Q99835 (/IDA) |
|
Patched binding GO:0005113
Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins.
|
2 | P56726 (/ISO) P56726 (/ISO) |
|
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
|
2 | P56726 (/ISO) P56726 (/ISO) |
|
Patched binding GO:0005113
Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins.
|
1 | Q99835 (/IPI) |
|
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
|
1 | P97698 (/ISS) |
Showing 1 to 7 of 7 entries
There are 171 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
|
6 | P56726 (/IMP) P56726 (/IMP) Q5RH73 (/IMP) Q90X26 (/IMP) Q90YY4 (/IMP) Q99835 (/IMP) |
|
Vasculogenesis GO:0001570
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
|
5 | P56726 (/IMP) P56726 (/IMP) Q5RH73 (/IMP) Q90X26 (/IMP) Q90YY4 (/IMP) |
|
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
|
5 | P56726 (/IMP) P56726 (/IMP) Q5RH73 (/IMP) Q90X26 (/IMP) Q90YY4 (/IMP) |
|
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
5 | P56726 (/IMP) P56726 (/IMP) Q5RH73 (/IMP) Q90X26 (/IMP) Q90YY4 (/IMP) |
|
Positive regulation of smoothened signaling pathway GO:0045880
Any process that activates or increases the frequency, rate or extent of smoothened signaling.
|
5 | P56726 (/IMP) P56726 (/IMP) Q5RH73 (/IMP) Q90X26 (/IMP) Q90YY4 (/IMP) |
|
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
|
5 | P56726 (/IMP) P56726 (/IMP) Q5RH73 (/IMP) Q90X26 (/IMP) Q90YY4 (/IMP) |
|
Somite development GO:0061053
The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
5 | P56726 (/IMP) P56726 (/IMP) Q5RH73 (/IMP) Q90X26 (/IMP) Q90YY4 (/IMP) |
|
Commissural neuron axon guidance GO:0071679
The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
4 | P97698 (/IMP) Q5RH73 (/IMP) Q90X26 (/IMP) Q90YY4 (/IMP) |
|
Neural plate morphogenesis GO:0001839
The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.
|
3 | Q5RH73 (/IMP) Q90X26 (/IMP) Q90YY4 (/IMP) |
|
Cardiac ventricle development GO:0003231
The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
|
3 | Q5RH73 (/IMP) Q90X26 (/IMP) Q90YY4 (/IMP) |
Showing 1 to 10 of 171 entries
There are 28 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
|
5 | P56726 (/IDA) P56726 (/IDA) Q5RH73 (/IDA) Q90X26 (/IDA) Q90YY4 (/IDA) |
|
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
|
5 | P97698 (/ISS) Q5RH73 (/ISS) Q90X26 (/ISS) Q90YY4 (/ISS) Q99835 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | P56726 (/IDA) P56726 (/IDA) P97698 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P56726 (/IDA) P56726 (/IDA) Q99835 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P56726 (/ISS) P56726 (/ISS) P97698 (/ISS) |
|
Endocytic vesicle membrane GO:0030666
The lipid bilayer surrounding an endocytic vesicle.
|
3 | P56726 (/TAS) P56726 (/TAS) Q99835 (/TAS) |
|
Ciliary membrane GO:0060170
The portion of the plasma membrane surrounding a cilium.
|
3 | P56726 (/TAS) P56726 (/TAS) Q99835 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P56726 (/ISO) P56726 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P56726 (/ISO) P56726 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P56726 (/ISO) P56726 (/ISO) |
Showing 1 to 10 of 28 entries
