The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"BEACH domain
".
FunFam 3: WD repeat-containing protein 81 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Phosphatidylinositol 3-kinase regulator activity GO:0035014
Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
|
4 | D4A929 (/ISS) E7FEV0 (/ISS) Q10122 (/ISS) Q5ND34 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | F4JY12 (/IPI) Q10122 (/IPI) Q562E7 (/IPI) |
|
K63-linked polyubiquitin modification-dependent protein binding GO:0070530
Interacting selectively and non-covalently with a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein.
|
2 | D4A929 (/ISS) Q5ND34 (/ISS) |
|
Phosphatidylinositol 3-kinase regulator activity GO:0035014
Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
|
1 | Q562E7 (/IMP) |
|
Phosphatidylinositol 3-kinase regulator activity GO:0035014
Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.
|
1 | Q5ND34 (/ISO) |
|
K63-linked polyubiquitin modification-dependent protein binding GO:0070530
Interacting selectively and non-covalently with a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein.
|
1 | Q562E7 (/IDA) |
|
K63-linked polyubiquitin modification-dependent protein binding GO:0070530
Interacting selectively and non-covalently with a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein.
|
1 | Q5ND34 (/ISO) |
There are 25 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of phosphatidylinositol 3-kinase activity GO:0043551
Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring.
|
4 | D4A929 (/ISS) E7FEV0 (/ISS) Q10122 (/ISS) Q5ND34 (/ISS) |
|
Early endosome to late endosome transport GO:0045022
The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
|
4 | D4A929 (/ISS) E7FEV0 (/ISS) Q10122 (/ISS) Q5ND34 (/ISS) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
3 | D4A929 (/ISS) E7FEV0 (/ISS) Q5ND34 (/ISS) |
|
Aggrephagy GO:0035973
Selective degradation of protein aggregates by macroautophagy.
|
3 | D4A929 (/ISS) E7FEV0 (/ISS) Q5ND34 (/ISS) |
|
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
|
2 | D4A929 (/ISS) Q562E7 (/ISS) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | Q562E7 (/IMP) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | Q5ND34 (/ISO) |
|
Protein targeting to vacuole GO:0006623
The process of directing proteins towards the vacuole, usually using signals contained within the protein.
|
1 | F4JY12 (/IMP) |
|
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
|
1 | Q5ND34 (/IMP) |
|
Defense response to bacterium, incompatible interaction GO:0009816
A response of an organism to a bacterium that prevents the occurrence or spread of disease.
|
1 | F4JY12 (/IMP) |
|
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
|
1 | Q562E7 (/IDA) |
|
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
|
1 | Q5ND34 (/ISO) |
|
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
|
1 | Q5ND34 (/ISS) |
|
Aggrephagy GO:0035973
Selective degradation of protein aggregates by macroautophagy.
|
1 | Q562E7 (/IMP) |
|
Aggrephagy GO:0035973
Selective degradation of protein aggregates by macroautophagy.
|
1 | Q5ND34 (/ISO) |
|
Regulation of phosphatidylinositol 3-kinase activity GO:0043551
Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring.
|
1 | Q562E7 (/IMP) |
|
Regulation of phosphatidylinositol 3-kinase activity GO:0043551
Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring.
|
1 | Q5ND34 (/ISO) |
|
Early endosome to late endosome transport GO:0045022
The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
|
1 | Q562E7 (/IMP) |
|
Early endosome to late endosome transport GO:0045022
The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
|
1 | Q5ND34 (/ISO) |
|
Organelle fusion GO:0048284
The creation of a single organelle from two or more organelles.
|
1 | Q10122 (/IGI) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | Q562E7 (/IMP) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | Q5ND34 (/ISO) |
|
Regulation of endosome size GO:0051036
Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis.
|
1 | Q10122 (/IGI) |
|
Positive regulation of early endosome to late endosome transport GO:2000643
Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport.
|
1 | Q10122 (/IGI) |
|
Positive regulation of early endosome to late endosome transport GO:2000643
Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport.
|
1 | Q10122 (/IMP) |
There are 23 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | D4A929 (/ISS) E7FEV0 (/ISS) Q10122 (/ISS) Q5ND34 (/ISS) |
|
Extrinsic component of endosome membrane GO:0031313
The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
4 | D4A929 (/ISS) E7FEV0 (/ISS) Q10122 (/ISS) Q5ND34 (/ISS) |
|
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
4 | D4A929 (/ISS) E7FEV0 (/ISS) Q10122 (/ISS) Q5ND34 (/ISS) |
|
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
|
4 | D4A929 (/ISS) E7FEV0 (/ISS) Q10122 (/ISS) Q5ND34 (/ISS) |
|
Autophagosome membrane GO:0000421
The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
|
3 | D4A929 (/ISS) E7FEV0 (/ISS) Q5ND34 (/ISS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | Q562E7 (/IDA) Q5ND34 (/IDA) |
|
Autophagosome membrane GO:0000421
The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
|
1 | Q562E7 (/IDA) |
|
Autophagosome membrane GO:0000421
The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
|
1 | Q5ND34 (/ISO) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q5ND34 (/ISO) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | D4A929 (/ISS) |
|
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
|
1 | Q562E7 (/IDA) |
|
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
|
1 | Q5ND34 (/ISO) |
|
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
1 | Q10122 (/IDA) |
|
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
|
1 | Q10122 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q562E7 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q5ND34 (/ISO) |
|
Extrinsic component of endosome membrane GO:0031313
The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
1 | Q562E7 (/IDA) |
|
Extrinsic component of endosome membrane GO:0031313
The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
1 | Q5ND34 (/ISO) |
|
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
1 | Q562E7 (/IDA) |
|
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
|
1 | Q5ND34 (/ISO) |
|
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
|
1 | Q562E7 (/IDA) |
|
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
|
1 | Q5ND34 (/ISO) |
|
Cul4-RING E3 ubiquitin ligase complex GO:0080008
A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
|
1 | F4JY12 (/ISS) |
