The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Transcription Factor, Ets-1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1liprin-alpha-2 isoform X1ankyrin repeat and sterile alpha motif domain-containing protein 1BConnector enhancer of kinase suppressor of Ras 2Ankyrin repeat and sterile alpha motif domain-containing 6Ephrin type-A receptor 1Protein vts1, variantankyrin repeat and SAM domain-containing protein 4BPutative sam and sh3 domain-containing protein 1GRB2-associated and regulator of MAPK protein 1phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2Bifunctional apoptosis regulatorSterile alpha motif domain containing 5Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3ephrin type-A receptor 8Smg, isoform Bpolycomb protein Sfmbt isoform X1Actin cytoskeleton-regulatory complex protein SLA1Blast:Protein aveugleSC:2Polyhomeotic-like protein 2 isoform 1transcription factor ETV6GA-binding protein alpha chain, putativePhosphatidylcholine:ceramide cholinephosphotransferase 1SAM pointed domain containing ETS transcription factorLymphocyte cytosolic protein 2Ets DNA-binding protein pokkuriETS-related transcription factor Elf-3 isoform X1EPS8 like 2SC:3Poly [ADP-ribose] polymeraseAnkyrin repeat and sterile alpha motif domain-containing protein 1BTumor protein 63 (p63)Kinase suppressor of Ras 2SAM domain, SH3 domain and nuclear localization signals 1Serine/threonine-protein kinase STE11SC:4PTPRF interacting protein alpha 1Liprin-beta-1 isoform 1Epidermal growth factor receptor kinase substrate 8SC:5PTPRF interacting protein alpha 1Liprin-beta-1 isoform 1SH3 and multiple ankyrin repeat domains protein 2Neurabin-1 isoform 1-like proteinDiacylglycerol kinaseSAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1Ephrin type-A receptor 5Stromal interaction molecule 1Fli-1 proto-oncogene, ETS transcription factorProtein Smaug homolog 1 isoform 2Protein c-ets-1 isoform 1Liprin-beta-1 isoform 1Polycomb protein scmh1 isoform 4Transcription factor CP2 like 1Putative sam and sh3 domain-containing protein 1ETS homologous factor isoform X1scm-like with four MBT domains protein 2caskin-2 isoform X2caskin-1 isoform X1lethal(3)malignant brain tumor-like protein 3 isoform X2upstream-binding protein 1 isoform X1sphingomyelin synthase-related protein 1 isoform X1Chromosome 19 C19orf47 homologSterile alpha and TIR motif-containing 1kinase D-interacting substrate of 220 kDa isoform X1ephrin type-A receptor 3SEC23 interacting proteinkazrin isoform X1Kinesin family member 24Sterile alpha motif domain-containing proteinEctoderm-expressed 4, isoform DE3 ubiquitin-protein ligase LRSAM1 isoform X1Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1Sterile alpha and TIR motif containing 1arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1mitogen-activated protein kinase kinase kinase 20 isoform X1ephrin type-A receptor 10Ephrin type-B receptor 6mitochondrial import inner membrane translocase subunit TIM22-likeArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2Caskin, isoform DSexual stage-specific protein kinaseGemini, isoform CStromal interaction moleculeSerine/threonine-protein kinase STE11DDHD domain-containing 2Sterile alpha motif (SAM) domain-containing proteintranscription factor CP2-like protein 1 isoform X1Eph receptor tyrosine kinaseEPS8 like 3Polarized growth protein boi2Kinase suppressor of rasEPS (Human endocytosis) relatedLiprin-betaAlpha-globin transcription factor CP2Sterile alpha motif domain containing 9Uncharacterized protein, isoform AAnkyrin repeat, SAM and basic leucine zipper domain-containing 1Bem1 interacting proteinLiprin-betaSterile alpha motif domain-containing 7uncharacterized protein LOC108099255 isoform X1Sterile alpha motif domain containing 9 likeChromosome 19 C19orf47 homologLiprin-betaEPH receptor B2Polycomb protein ScmSterile alpha and TIR motif-containing protein tir-1uncharacterized protein LOC108093779Bicaudal C, isoform BUncharacterized protein, isoform BDiacylglycerol kinaseMAPKKK cascade protein kinase regulator Ste50 (AFU_orthologue AFUA_2G17130)Uncharacterized protein, isoform ASte50pMammalian ZAK kinase homologPredicted proteinPhospholipase DDHD2DNA-binding protein D-ETS-6Kinesin-like proteinEndonuclease III homologKinase suppressor of RasProtein CBR-TAG-97Kinesin-like proteinAdenylate cyclase, class 3stromal interaction molecule 2CG5272 proteinTranscription factor ets-4AGAP009560-PA-like proteinProtein CBG01454Zmp:0000000735Predicted proteinUncharacterized proteinProbable serine/threonine-protein kinase DDB_G0278535Serine/threonine-protein kinase, putativeUncharacterized proteinPredicted proteinets protein isoform X1Protein matrimonyProtein VTS1Sphingomyelin synthase-related 1E74-like factor 3 (ets domain transcription factor, epithelial-specific )Uncharacterized proteinEphrin type-A receptor 5Uncharacterized proteinUncharacterized proteinPredicted proteinGD15078GH09064pPhosphatidylinositol 3-kinase regulatory subunit alpha-like Proteinphosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X1Probable serine/threonine-protein kinase samkCuncharacterized protein LOC100179383 isoform X1SAM_domain_(Sterile_alpha_motif)_-_putativePutative ets proteinous factorEphrin type-A receptor 4-BUncharacterized proteinProtein CBG04143STE11Uncharacterized protein, isoform AMAP kinaseLeucine-rich repeat and sterile alpha motif-containing 1Putative adenylate cyclasestromal interaction molecule homolog isoform X3Mitogen-activated protein kinase kinase kinaseSerine/threonine-protein kinase STE11Kinase suppressor of ras 1Tyrosine kinase, non-receptor, 1Uncharacterized proteinUncharacterized proteinSphingomyelin synthase-related protein 1Uncharacterized proteinProtein Smaug homolog 2Uncharacterized proteinsphingomyelin synthase-related protein 1E74 like ETS transcription factor 3Ephrin receptorEphrin receptorReceptor protein-tyrosine kinaseProtein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),-interacting protein (liprin), alpha 1Predicted proteinMitogen-activated protein kinase kinase kinase 15Predicted proteinArrestin domain-containing protein BUncharacterized proteinPredicted proteinEpidermal growth factor receptor kinase substrate 8Uncharacterized proteinCaskin-1Leucine-rich repeat and sterile alpha motif-containing 1Kinase suppressor of Ras 2-like ProteinKinase suppressor of Ras 2Caskin-1Stromal interaction molecule 1Poly [ADP-ribose] polymerasePutative sh3 and multiple ankyrin repeat 3Uncharacterized proteinAFR092WpGA repeat binding protein alpha homolog isoform X1Predicted proteinReceptor protein-tyrosine kinaseKinase, putativeNGFI-A-binding protein 1a (EGR1 binding protein 1)Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinSec-23 interacting protein P125, putativeFli-1 proto-oncogene, ETS transcription factor aPredicted proteinUncharacterized proteinPredicted proteinDDHD domain-containing 2Uncharacterized proteinB cell linkerUncharacterized proteinPredicted proteinPredicted proteinSphingomyelin synthase-related 1-like ProteinUncharacterized proteinUncharacterized proteinUncharacterized proteintranscription factor proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinEph receptor A4,-likeEPH receptor A5Uncharacterized proteinUncharacterized proteinPredicted proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinDual specificity protein kinase splAKinesin-related protein 6Uncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted protein
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FunFam 70: ArfGAP with RhoGAP domain, ankyrin repeat and PH d...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
1 Q8WZ64 (/IDA)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
1 Q8BZ05 (/ISO)
Showing 1 to 2 of 2 entries

There are 1 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
1 Q8WZ64 (/TAS)
Showing 1 to 1 of 1 entries

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8WZ64 (/TAS)
Showing 1 to 1 of 1 entries
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