The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Transcription Factor, Ets-1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1liprin-alpha-2 isoform X1ankyrin repeat and sterile alpha motif domain-containing protein 1BConnector enhancer of kinase suppressor of Ras 2Ankyrin repeat and sterile alpha motif domain-containing 6Ephrin type-A receptor 1Protein vts1, variantankyrin repeat and SAM domain-containing protein 4BPutative sam and sh3 domain-containing protein 1GRB2-associated and regulator of MAPK protein 1phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2Bifunctional apoptosis regulatorSterile alpha motif domain containing 5Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3ephrin type-A receptor 8Smg, isoform Bpolycomb protein Sfmbt isoform X1Actin cytoskeleton-regulatory complex protein SLA1Blast:Protein aveugleSC:2Polyhomeotic-like protein 2 isoform 1transcription factor ETV6GA-binding protein alpha chain, putativePhosphatidylcholine:ceramide cholinephosphotransferase 1SAM pointed domain containing ETS transcription factorLymphocyte cytosolic protein 2Ets DNA-binding protein pokkuriETS-related transcription factor Elf-3 isoform X1EPS8 like 2SC:3Poly [ADP-ribose] polymeraseAnkyrin repeat and sterile alpha motif domain-containing protein 1BTumor protein 63 (p63)Kinase suppressor of Ras 2SAM domain, SH3 domain and nuclear localization signals 1Serine/threonine-protein kinase STE11SC:4PTPRF interacting protein alpha 1Liprin-beta-1 isoform 1Epidermal growth factor receptor kinase substrate 8SC:5PTPRF interacting protein alpha 1Liprin-beta-1 isoform 1SH3 and multiple ankyrin repeat domains protein 2Neurabin-1 isoform 1-like proteinDiacylglycerol kinaseSAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1Ephrin type-A receptor 5Stromal interaction molecule 1Fli-1 proto-oncogene, ETS transcription factorProtein Smaug homolog 1 isoform 2Protein c-ets-1 isoform 1Liprin-beta-1 isoform 1Polycomb protein scmh1 isoform 4Transcription factor CP2 like 1Putative sam and sh3 domain-containing protein 1ETS homologous factor isoform X1scm-like with four MBT domains protein 2caskin-2 isoform X2caskin-1 isoform X1lethal(3)malignant brain tumor-like protein 3 isoform X2upstream-binding protein 1 isoform X1sphingomyelin synthase-related protein 1 isoform X1Chromosome 19 C19orf47 homologSterile alpha and TIR motif-containing 1kinase D-interacting substrate of 220 kDa isoform X1ephrin type-A receptor 3SEC23 interacting proteinkazrin isoform X1Kinesin family member 24Sterile alpha motif domain-containing proteinEctoderm-expressed 4, isoform DE3 ubiquitin-protein ligase LRSAM1 isoform X1Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1Sterile alpha and TIR motif containing 1arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1mitogen-activated protein kinase kinase kinase 20 isoform X1ephrin type-A receptor 10Ephrin type-B receptor 6mitochondrial import inner membrane translocase subunit TIM22-likeArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2Caskin, isoform DSexual stage-specific protein kinaseGemini, isoform CStromal interaction moleculeSerine/threonine-protein kinase STE11DDHD domain-containing 2Sterile alpha motif (SAM) domain-containing proteintranscription factor CP2-like protein 1 isoform X1Eph receptor tyrosine kinaseEPS8 like 3Polarized growth protein boi2Kinase suppressor of rasEPS (Human endocytosis) relatedLiprin-betaAlpha-globin transcription factor CP2Sterile alpha motif domain containing 9Uncharacterized protein, isoform AAnkyrin repeat, SAM and basic leucine zipper domain-containing 1Bem1 interacting proteinLiprin-betaSterile alpha motif domain-containing 7uncharacterized protein LOC108099255 isoform X1Sterile alpha motif domain containing 9 likeChromosome 19 C19orf47 homologLiprin-betaEPH receptor B2Polycomb protein ScmSterile alpha and TIR motif-containing protein tir-1uncharacterized protein LOC108093779Bicaudal C, isoform BUncharacterized protein, isoform BDiacylglycerol kinaseMAPKKK cascade protein kinase regulator Ste50 (AFU_orthologue AFUA_2G17130)Uncharacterized protein, isoform ASte50pMammalian ZAK kinase homologPredicted proteinPhospholipase DDHD2DNA-binding protein D-ETS-6Kinesin-like proteinEndonuclease III homologKinase suppressor of RasProtein CBR-TAG-97Kinesin-like proteinAdenylate cyclase, class 3stromal interaction molecule 2CG5272 proteinTranscription factor ets-4AGAP009560-PA-like proteinProtein CBG01454Zmp:0000000735Predicted proteinUncharacterized proteinProbable serine/threonine-protein kinase DDB_G0278535Serine/threonine-protein kinase, putativeUncharacterized proteinPredicted proteinets protein isoform X1Protein matrimonyProtein VTS1Sphingomyelin synthase-related 1E74-like factor 3 (ets domain transcription factor, epithelial-specific )Uncharacterized proteinEphrin type-A receptor 5Uncharacterized proteinUncharacterized proteinPredicted proteinGD15078GH09064pPhosphatidylinositol 3-kinase regulatory subunit alpha-like Proteinphosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X1Probable serine/threonine-protein kinase samkCuncharacterized protein LOC100179383 isoform X1SAM_domain_(Sterile_alpha_motif)_-_putativePutative ets proteinous factorEphrin type-A receptor 4-BUncharacterized proteinProtein CBG04143STE11Uncharacterized protein, isoform AMAP kinaseLeucine-rich repeat and sterile alpha motif-containing 1Putative adenylate cyclasestromal interaction molecule homolog isoform X3Mitogen-activated protein kinase kinase kinaseSerine/threonine-protein kinase STE11Kinase suppressor of ras 1Tyrosine kinase, non-receptor, 1Uncharacterized proteinUncharacterized proteinSphingomyelin synthase-related protein 1Uncharacterized proteinProtein Smaug homolog 2Uncharacterized proteinsphingomyelin synthase-related protein 1E74 like ETS transcription factor 3Ephrin receptorEphrin receptorReceptor protein-tyrosine kinaseProtein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),-interacting protein (liprin), alpha 1Predicted proteinMitogen-activated protein kinase kinase kinase 15Predicted proteinArrestin domain-containing protein BUncharacterized proteinPredicted proteinEpidermal growth factor receptor kinase substrate 8Uncharacterized proteinCaskin-1Leucine-rich repeat and sterile alpha motif-containing 1Kinase suppressor of Ras 2-like ProteinKinase suppressor of Ras 2Caskin-1Stromal interaction molecule 1Poly [ADP-ribose] polymerasePutative sh3 and multiple ankyrin repeat 3Uncharacterized proteinAFR092WpGA repeat binding protein alpha homolog isoform X1Predicted proteinReceptor protein-tyrosine kinaseKinase, putativeNGFI-A-binding protein 1a (EGR1 binding protein 1)Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinSec-23 interacting protein P125, putativeFli-1 proto-oncogene, ETS transcription factor aPredicted proteinUncharacterized proteinPredicted proteinDDHD domain-containing 2Uncharacterized proteinB cell linkerUncharacterized proteinPredicted proteinPredicted proteinSphingomyelin synthase-related 1-like ProteinUncharacterized proteinUncharacterized proteinUncharacterized proteintranscription factor proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinEph receptor A4,-likeEPH receptor A5Uncharacterized proteinUncharacterized proteinPredicted proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinDual specificity protein kinase splAKinesin-related protein 6Uncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted protein
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FunFam 61: Ets DNA-binding protein pokkuri

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q01842 (/IPI) Q01842 (/IPI) Q7K119 (/IPI)
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
2 Q01842 (/IDA) Q01842 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 Q01842 (/IDA) Q01842 (/IDA)
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
2 Q01842 (/IDA) Q01842 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 Q01842 (/IDA) Q01842 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q01842 (/IDA) Q01842 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 Q01842 (/IPI) Q01842 (/IPI)
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
1 Q7K119 (/IPI)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
1 Q7K119 (/IDA)
Showing 1 to 9 of 9 entries

There are 42 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q01842 (/IDA) Q01842 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q01842 (/IMP) Q01842 (/IMP)
Cell fate determination GO:0001709
A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
2 Q01842 (/IMP) Q01842 (/IMP)
Compound eye photoreceptor cell differentiation GO:0001751
The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.
2 Q01842 (/IMP) Q01842 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
2 Q01842 (/IMP) Q01842 (/IMP)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 Q01842 (/IMP) Q01842 (/IMP)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
2 Q01842 (/IMP) Q01842 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
2 Q01842 (/TAS) Q01842 (/TAS)
R3/R4 cell fate commitment GO:0007464
The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres.
2 Q01842 (/IMP) Q01842 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
2 Q01842 (/IGI) Q01842 (/IGI)
Showing 1 to 10 of 42 entries

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q01842 (/HDA) Q01842 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q01842 (/IDA) Q01842 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q01842 (/IMP) Q01842 (/IMP)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q01842 (/HDA) Q01842 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q01842 (/IDA) Q01842 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q01842 (/HDA) Q01842 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q01842 (/IDA) Q01842 (/IDA)
Showing 1 to 7 of 7 entries
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