The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"5' to 3' exonuclease, C-terminal subdomain
".
FunFam 8: DNA repair protein RAD51 homolog
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 21 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
11 |
G5EGG8 (/IPI)
P25454 (/IPI)
P25454 (/IPI)
P25454 (/IPI)
P25454 (/IPI)
P25454 (/IPI)
P25454 (/IPI)
P36601 (/IPI)
P94102 (/IPI)
P94102 (/IPI)
(1 more) |
Recombinase activity GO:0000150
Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
|
9 | G5EGG8 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P36601 (/IDA) Q95Q25 (/IDA) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
9 | G5EGG8 (/IPI) P25454 (/IPI) P25454 (/IPI) P25454 (/IPI) P25454 (/IPI) P25454 (/IPI) P25454 (/IPI) P36601 (/IPI) Q95Q25 (/IPI) |
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
8 | A3E3X4 (/ISS) A3E3X4 (/ISS) A3E3X6 (/ISS) A3E3X6 (/ISS) B6JXU7 (/ISS) Q91917 (/ISS) Q91917 (/ISS) Q91918 (/ISS) |
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
8 | O61127 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P36601 (/IDA) |
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
|
8 | A3E3X4 (/ISS) A3E3X4 (/ISS) A3E3X6 (/ISS) A3E3X6 (/ISS) B6JXU7 (/ISS) Q91917 (/ISS) Q91917 (/ISS) Q91918 (/ISS) |
DNA-dependent ATPase activity GO:0008094
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.
|
8 | G5EGG8 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) Q95Q25 (/IDA) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
6 | P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) |
Recombinase activity GO:0000150
Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
|
5 | A3E3X4 (/ISS) A3E3X4 (/ISS) A3E3X6 (/ISS) A3E3X6 (/ISS) B6JXU7 (/ISS) |
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
5 | A3E3X4 (/ISS) A3E3X4 (/ISS) A3E3X6 (/ISS) A3E3X6 (/ISS) B6JXU7 (/ISS) |
Showing 1 to 10 of 21 entries
There are 44 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Double-strand break repair via homologous recombination GO:0000724
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
|
8 | C8VSQ3 (/IMP) C8VSQ3 (/IMP) P36601 (/IMP) Q59UY8 (/IMP) Q59UY8 (/IMP) Q59UY8 (/IMP) Q5TYR1 (/IMP) Q6P5K8 (/IMP) |
Strand invasion GO:0042148
The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.
|
7 | P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P36601 (/IDA) |
Meiotic joint molecule formation GO:0000709
The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA.
|
6 | P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) |
Telomere maintenance via recombination GO:0000722
Any recombinational process that contributes to the maintenance of proper telomeric length.
|
6 | P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) |
Double-strand break repair via homologous recombination GO:0000724
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
|
6 | P25454 (/TAS) P25454 (/TAS) P25454 (/TAS) P25454 (/TAS) P25454 (/TAS) P25454 (/TAS) |
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
|
6 | P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) |
Reciprocal meiotic recombination GO:0007131
The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.
|
6 | P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) |
Heteroduplex formation GO:0030491
The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules.
|
6 | P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) |
Mitochondrial DNA repair GO:0043504
The process of restoring mitochondrial DNA after damage.
|
6 | P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) P25454 (/IMP) |
Double-strand break repair via homologous recombination GO:0000724
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
|
3 | Q91917 (/ISS) Q91917 (/ISS) Q91918 (/ISS) |
Showing 1 to 10 of 44 entries
There are 15 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
|
8 | G5EGG8 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) Q95Q25 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | G5EGG8 (/IDA) P94102 (/IDA) P94102 (/IDA) Q384K0 (/IDA) Q384K0 (/IDA) Q384K0 (/IDA) Q95Q25 (/IDA) |
Nuclear chromosome GO:0000228
A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
|
6 | P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
6 | P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) P25454 (/IDA) |
Site of double-strand break GO:0035861
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
|
5 | P36601 (/IDA) Q384K0 (/IDA) Q384K0 (/IDA) Q384K0 (/IDA) Q95Q25 (/IDA) |
Nuclear chromosome GO:0000228
A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
|
3 | Q91917 (/ISS) Q91917 (/ISS) Q91918 (/ISS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q91917 (/ISS) Q91917 (/ISS) Q91918 (/ISS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q91917 (/ISS) Q91917 (/ISS) Q91918 (/ISS) |
Chromosome GO:0005694
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
|
2 | P94102 (/IDA) P94102 (/IDA) |
Germ cell nucleus GO:0043073
The nucleus of a germ cell, a reproductive cell in multicellular organisms.
|
2 | G5EGG8 (/IDA) Q95Q25 (/IDA) |
Showing 1 to 10 of 15 entries