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CATH Superfamily 1.10.150.20

5' to 3' exonuclease, C-terminal subdomain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
5' to 3' exonuclease, C-terminal subdomain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1DNA repair protein RAD51 homologSC:2DNA-directed RNA polymerase subunit alphaUvrABC system protein CDNA ligaseDNA repair protein RAD51 homologHolliday junction ATP-dependent DNA helicase RuvATranscription termination/antitermination protein NusAHolliday junction ATP-dependent DNA helicase RuvADNA-directed DNA polymerase, family XSC:3DNA excision repair protein ERCC-1DNA polymerase betaDNA repair endonuclease XPF isoform X2Fanconi anemia, complementation group MATP-dependent RNA helicase, putativeSC:4DNA-directed RNA polymeraseSC:5Polymerase (DNA directed), etaDNA polymerase IVDNA repair protein REV1DNA polymerase iotaDNA repair protein REV1DNA polymerase etaSC:6DNA polymerase Iexonuclease 1T5 flap endonucleaseSC:7DNA ligaseFanconi anemia core complex-associated protein 24DNA polymeraseDNA integrity scanning protein DisADNA polymerase IU5 small nuclear ribonucleoprotein helicaseFlap endonuclease 1DNA polymerase lambdaU5 small nuclear ribonucleoprotein kDa helicaseTranscription termination/antitermination protein NusADNA integrity scanning protein DisADNA-directed RNA polymerase subunit alphaDNA-directed RNA polymerase subunit alphatranslocation protein SEC63 homologDNA integrity scanning protein DisADNA polymerase gamma, catalytic subunitDNA-directed RNA polymeraseactivating signal cointegrator 1 complex subunit 3Flap endonuclease GEN-like 1DNA-directed RNA polymerasemeiotic recombination protein DMC1/LIM15 homologTfoX family proteinDNA polymerase IDNA polymerase gamma, mitochondrialPolymerase (DNA directed), thetaDNA repair protein complementing XP-G cells homologDNA repair endonuclease UVH1Polymerase (DNA directed) kappaDNA-directed RNA polymerase5'-3' exonuclease family proteinMeiotic recombination protein DMC1 homologDnaJ protein ERDJ2ADNA polymerase V subunitDNA-directed RNA polymerase subunit alphaPlastid replication-repair enzymeDNA repair protein UVH3Endonuclease, putativeDNA repair protein RAD51 homologMating-type switch/DNA repair protein Swi10/Rad10Meiotic recombination protein DMC1RAD2p Single-stranded DNA endonucleaseHelicase, POLQ likeMitochondrial DNA polymerase I protein CDNA polymerase IVDNA polymerase IVDNA repair protein RAD1Bifunctional 3'-5' exonuclease/DNA polymeraseTranscription termination/antitermination protein NusADNA polymerase ADNA polymerase IVExonuclease 1DNA polymerase I, putativeFlap endonuclease 1Pre-mRNA-splicing helicase BRR2, putativeTranslocation protein SEC63DNA-directed RNA polymeraseMeiotic recombination protein DMC1DNA repair endonuclease, putativeDExH-box ATP-dependent RNA helicase DExH17DNA-directed RNA polymerase subunit alphaPutative DNA repair endonucleaseMeiotic recombination protein DMC1Protein translocation complex component (Npl1)DNA-directed RNA polymerase, mitochondrialPutative DNA polymerase 1ERCC1 nucleotide excision repair protein, putativeDNA polymerase ITranslocation protein SEC63Flap endonuclease 1DNA repair protein RadCDNA repair proteinU5 small nuclear ribonucleoprotein helicaseUnplaced genomic scaffold supercont1.20, whole genome shotgun sequenceDNA excision repair protein Rad2DNA polymerase IVExonuclease I, putativePutative DNA polymerase kappaMeiotic recombinase Dmc1RNA polymerase alpha subunit domain proteinDNA ligase BDNA ligaseTranscription termination/antitermination protein NusAUvrABC system protein CDNA-directed RNA polymerase subunit alphaUnplaced genomic scaffold supercont1.24, whole genome shotgun sequenceDNA ligase5'-3' exonucleaseDNA repair endonuclease XPFDNA ligasetRNA-specific adenosine deaminaseProtein CBG20918DNA polymerase IVDNA ligaseDNA polymerase theta, putativeDNA-directed RNA polymeraseDNA ligaseTranslocation protein SEC63flap endonuclease GEN-like 2 isoform X1GM24241DNA-directed RNA polymerase subunit alphaDNA-directed RNA polymerase subunit alphaDNA-directed RNA polymerase subunit alphaExonuclease, putativeDNA polymerase subunit gamma-1, mitochondrialDNA repair protein RAD51 homologUnplaced genomic scaffold supercont1.238, whole genome shotgun sequenceDNA-directed RNA polymeraseDNA polymerase IV5'-3' exonucleaseUvrABC system protein CExonuclease-1, H3TH domain proteinDNA repair protein RAD51 homologImpB/MucB/SamB family proteinMitochondrial DNA polymerase beta-PAK, putativeDNA ligase BDNApol-iota, isoform ADNA-dependent RNA polymeraseDNA ligaseDNA-directed RNA polymerase subunit alphaHolliday junction ATP-dependent DNA helicase RuvAExonuclease I, putativeDNA excision repair protein, putativeDNA repair endonuclease XPFDNA repair endonuclease xp-f, putativeDNaJ domain (Prokaryotic heat shock protein)Transcription termination/antitermination protein NusAUncharacterized proteinDNA ligasePredicted proteinTranscription termination/antitermination protein NusAUvrABC system protein CUvrABC system protein CPutative DNA repair proteinChromosome 8, whole genome shotgun sequenceFA core complex associated protein 24DNA polymerase lambda subunit5'-3' exonuclease family proteinProbable DNA polymerase X-putativeDNA-directed RNA polymeraseDNA ligaseHolliday junction ATP-dependent DNA helicase RuvADNA-directed RNA polymerase subunit alphaTranscription and mRNA export factor ENY2Mating-type switching protein swi10DNA repair protein Rad1 homologue, putativeUvrABC system protein CUvrABC system protein CMeiotic recombination protein (Dmc1), putative (AFU_orthologue AFUA_7G02200)DNA transformation protein TfoX1ATP-dependent DNA helicase Hel308ATP-dependent DNA helicase Hel308DNA ligase BATP-dependent DNA helicaseDNA-directed RNA polymerase subunit alphaDNA-directed DNA polymerase etaDNA repair enzymeExonuclease I, putativeUncharacterized proteinTranscription termination/antitermination protein NusADNA excision repair protein ERCC-1DNA repair endonuclease XPFYALI0B22242pProtein CBR-ERCC-1Restriction endonuclease type II-like proteinDmc1bDNA-binding protein MutS2Flap structure-specific endonuclease5' flap endonuclease, putativeDNA polymerase IDNA polymerase IVDNA polymerase etaDNA polymerase nuAGAP007361-PADNA polymerase nuDNA-directed RNA polymerase subunit alpha, chloroplasticDNA damage repair protein, putativeDNA polymerase IVNucleotide excision repair proteinFlap endonuclease 1PIN domain-like proteinGH27547pTranscription termination/antitermination protein NusAUvrABC system protein CMeiotic recombination protein DMC1DNA ligaseDNA excision repair protein ERCC-1Rad10pAGAP002805-PADNA repair proteinUncharacterized proteinFanconi anemia core complex-associated protein 24DNA repair protein RAD51 homologDNA repair and recombination protein RadAUncharacterized proteinUvrABC system protein CUvrABC system protein CUncharacterized proteinRNA helicase, activating signal cointegrator 1YALI0F20724pDNA polymerase IUPF0758 protein SPO0054Protein CBR-XPG-1DNA repair protein complementing XP-G cells-like isoform X1DNA polymeraseUncharacterized proteinDNA polymeraseYALI0D12364pDNA polymeraseDNA polymeraseDNA-dependent RNA polymeraseUncharacterized proteinDNA transformation protein tfoXCytosolic Fe-S cluster assembly factor NUBP1 homologUbiquitin carrier protein 7DNA transformation protein TfoX2DNA polymeraseDNA polymerase nuUncharacterized proteinTranslocation protein SEC63-like proteinTranscription termination/antitermination protein NusADNA topoisomerase IUncharacterized proteinDNA polymerase thetaDNA ligaseDNA-directed RNA polymerase subunit alphaDNA polymerase IVDNA polymerase IVDNA polymerase IVYALI0C01573pDNA polymerase IVDNA polymerase IVGEN1 Holliday junction resolvase homologFlap endonuclease 1Flap endonuclease 1Probable DNA-directed RNA polymeraseDNA repair protein, putativeProtein PARTING DANCERS50S ribosomal protein L32eUvrABC system protein CERCC (DNA excision repair protein) homologPredicted proteinPredicted proteinUncharacterized proteinFA core complex-associated protein 24Uncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinMeiotic 9Predicted proteinDNA repair protein rad16ERCC4 domain containing proteinFA core complex associated protein 24FA core complex-associated protein 24Uncharacterized proteinDNA repair protein RAD51 homologUncharacterized proteinUncharacterized proteinUncharacterized proteinMeiotic recombination protein DMC1-like proteinUvrABC system protein CUvrABC system protein CUncharacterized proteinUncharacterized proteinDNA-directed DNA/RNA polymerase muDNA nucleotidylexotransferaseDNA-directed RNA polymeraseDNA-directed RNA polymeraseDNA-directed RNA polymeraseDNA-directed RNA polymeraseDNA polymerase I family proteinUncharacterized proteinPolI-like DNA polymeraseUncharacterized proteinUncharacterized proteinDNA-directed RNA polymerase, mitochondrialDNA repair protein rev1Uncharacterized proteinUncharacterized proteinNADH:ubiquinone oxidoreductase 41 kD complex I subunit1,4-alpha-glucan branching enzyme TK1436DNA polymerase etaDNAJ domain containing proteinUncharacterized proteinUncharacterized proteinDNA topoisomerase 1Uncharacterized proteinDNA polymerase iotaUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinPredicted proteinPredicted proteinDNA-directed RNA polymerase subunit alphaDNA polymerase IVDNA polymerase IVUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinXp-G/rad2 DNA repair endonuclease, putativeUncharacterized proteinRAD51 recombinaseUncharacterized proteinDNA-directed RNA polymeraseUncharacterized proteinUncharacterized proteinUvrABC system protein C
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FunFam 56: Meiotic recombination protein DMC1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Recombinase activity GO:0000150
Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
 17 P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P50265 (/ISS) Q0MR21 (/ISS) Q0MR21 (/ISS)
(7 more)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
 17 P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P50265 (/ISS) Q0MR21 (/ISS) Q0MR21 (/ISS)
(7 more)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
 17 P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P50265 (/ISS) Q0MR21 (/ISS) Q0MR21 (/ISS)
(7 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
 17 P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P50265 (/ISS) Q0MR21 (/ISS) Q0MR21 (/ISS)
(7 more)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
 17 P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P25453 (/ISS) P50265 (/ISS) Q0MR21 (/ISS) Q0MR21 (/ISS)
(7 more)
Recombinase activity GO:0000150
Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
 7 P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
 7 P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
 7 P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 7 P25453 (/IPI) P25453 (/IPI) P25453 (/IPI) P25453 (/IPI) P25453 (/IPI) P25453 (/IPI) P25453 (/IPI)
ATPase inhibitor activity GO:0042030
Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate.
 7 P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA)
Showing 1 to 10 of 12 entries

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Meiotic joint molecule formation GO:0000709
The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA.
 7 P25453 (/IMP) P25453 (/IMP) P25453 (/IMP) P25453 (/IMP) P25453 (/IMP) P25453 (/IMP) P25453 (/IMP)
Synaptonemal complex assembly GO:0007130
The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination.
 7 P25453 (/IGI) P25453 (/IGI) P25453 (/IGI) P25453 (/IGI) P25453 (/IGI) P25453 (/IGI) P25453 (/IGI)
Reciprocal meiotic recombination GO:0007131
The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.
 7 P25453 (/IMP) P25453 (/IMP) P25453 (/IMP) P25453 (/IMP) P25453 (/IMP) P25453 (/IMP) P25453 (/IMP)
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
 7 P25453 (/IMP) P25453 (/IMP) P25453 (/IMP) P25453 (/IMP) P25453 (/IMP) P25453 (/IMP) P25453 (/IMP)
Meiotic joint molecule formation GO:0000709
The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA.
 1 A0A1D8PFE4 (/IGI)
Showing 1 to 5 of 5 entries

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
 7 P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 7 P25453 (/HDA) P25453 (/HDA) P25453 (/HDA) P25453 (/HDA) P25453 (/HDA) P25453 (/HDA) P25453 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 7 P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA) P25453 (/IDA)
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
 1 A0A1D8PFE4 (/IGI)
Showing 1 to 4 of 4 entries
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