The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
5' to 3' exonuclease, C-terminal subdomain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 12: Holliday junction ATP-dependent DNA helicase RuvA

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Four-way junction DNA binding GO:0000400
Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
146 P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA)
(136 more)
Four-way junction helicase activity GO:0009378
Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.
146 P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA)
(136 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
146 P0A809 (/IPI) P0A809 (/IPI) P0A809 (/IPI) P0A809 (/IPI) P0A809 (/IPI) P0A809 (/IPI) P0A809 (/IPI) P0A809 (/IPI) P0A809 (/IPI) P0A809 (/IPI)
(136 more)
Four-way junction helicase activity GO:0009378
Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.
7 Q9KR01 (/ISS) Q9KR01 (/ISS) Q9KR01 (/ISS) Q9KR01 (/ISS) Q9KR01 (/ISS) Q9KR01 (/ISS) Q9KR01 (/ISS)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
147 P0A809 (/IEP) P0A809 (/IEP) P0A809 (/IEP) P0A809 (/IEP) P0A809 (/IEP) P0A809 (/IEP) P0A809 (/IEP) P0A809 (/IEP) P0A809 (/IEP) P0A809 (/IEP)
(137 more)
Recombinational repair GO:0000725
A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.
146 P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP)
(136 more)
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
146 P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP) P0A809 (/IMP)
(136 more)
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
146 P0A809 (/RCA) P0A809 (/RCA) P0A809 (/RCA) P0A809 (/RCA) P0A809 (/RCA) P0A809 (/RCA) P0A809 (/RCA) P0A809 (/RCA) P0A809 (/RCA) P0A809 (/RCA)
(136 more)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
146 P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA)
(136 more)
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
7 Q9KR01 (/ISS) Q9KR01 (/ISS) Q9KR01 (/ISS) Q9KR01 (/ISS) Q9KR01 (/ISS) Q9KR01 (/ISS) Q9KR01 (/ISS)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Holliday junction helicase complex GO:0009379
A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA.
146 P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA)
(136 more)
Holliday junction resolvase complex GO:0048476
An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated.
146 P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA) P0A809 (/IDA)
(136 more)
CATH-Gene3D is a Global Biodata Core Resource Learn more...