The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
2'-5'-oligoadenylate synthetase 1, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: 2'-5'-oligoadenylate synthetase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
19 A8DPD5 (/ISS) A8YPE2 (/ISS) A8YPF0 (/ISS) A8YPF4 (/ISS) A8YPF5 (/ISS) A8YPF7 (/ISS) A8YPG1 (/ISS) F1N3B8 (/ISS) F1N3B8 (/ISS) F7EI59 (/ISS)
(9 more)
2'-5'-oligoadenylate synthetase activity GO:0001730
Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
17 A8DPD5 (/ISS) B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) B6RC74 (/ISS) F1N3B8 (/ISS) F1N3B8 (/ISS) F7EI55 (/ISS) F7EI59 (/ISS) F7I1U6 (/ISS)
(7 more)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
15 E9Q9A9 (/IDA) E9Q9A9 (/IDA) P00973 (/IDA) P11928 (/IDA) P29728 (/IDA) P29728 (/IDA) Q15646 (/IDA) Q60856 (/IDA) Q80VT1 (/IDA) Q8VI93 (/IDA)
(5 more)
2'-5'-oligoadenylate synthetase activity GO:0001730
Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
13 E9Q9A9 (/IDA) E9Q9A9 (/IDA) P00973 (/IDA) P11928 (/IDA) P29728 (/IDA) P29728 (/IDA) Q05961 (/IDA) Q29599 (/IDA) Q80VT1 (/IDA) Q8VI93 (/IDA)
(3 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
8 E9Q9A9 (/ISS) E9Q9A9 (/ISS) F1N3B8 (/ISS) F1N3B8 (/ISS) Q5MYT7 (/ISS) Q5MYU0 (/ISS) Q5MYU0 (/ISS) Q8VI93 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P00973 (/IPI) P11928 (/IPI) P29728 (/IPI) P29728 (/IPI) Q15646 (/IPI) Q60856 (/IPI) Q9Y6K5 (/IPI)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
6 E9Q9A9 (/ISO) E9Q9A9 (/ISO) P11928 (/ISO) Q8K469 (/ISO) Q8VI93 (/ISO) Q8VI94 (/ISO)
2'-5'-oligoadenylate synthetase activity GO:0001730
Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
5 E9Q9A9 (/ISO) E9Q9A9 (/ISO) P11928 (/ISO) Q8K469 (/ISO) Q8VI93 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
3 E9Q9A9 (/ISO) E9Q9A9 (/ISO) Q8VI93 (/ISO)
2'-5'-oligoadenylate synthetase activity GO:0001730
Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA.
2 P29728 (/IMP) P29728 (/IMP)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 G3V645 (/ISS) Q8VI94 (/ISS)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
2 P29728 (/IMP) P29728 (/IMP)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 P29728 (/IMP) P29728 (/IMP)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q15646 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q8VI94 (/ISO)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q15646 (/HDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q9Y6K5 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P00973 (/TAS)
Thyroid hormone receptor binding GO:0046966
Interacting selectively and non-covalently with a thyroid hormone receptor.
1 Q15646 (/TAS)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
20 A4LAA0 (/ISS) B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) B6RC68 (/ISS) B6RC73 (/ISS) B6RC74 (/ISS) F1N3B8 (/ISS) F1N3B8 (/ISS) F7EI55 (/ISS)
(10 more)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
15 A4LAA0 (/ISS) B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) B6RC68 (/ISS) B6RC73 (/ISS) B6RC74 (/ISS) F7EI55 (/ISS) F7EI59 (/ISS) F7I1U6 (/ISS)
(5 more)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
12 E9Q9A9 (/TAS) E9Q9A9 (/TAS) F1N3B8 (/TAS) F1N3B8 (/TAS) P11928 (/TAS) P29728 (/TAS) P29728 (/TAS) Q05961 (/TAS) Q5MYT9 (/TAS) Q5MYU0 (/TAS)
(2 more)
Regulation of ribonuclease activity GO:0060700
Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
10 A4LAA0 (/ISS) B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) B6RC68 (/ISS) B6RC73 (/ISS) F7EI55 (/ISS) F7I1U6 (/ISS) F7I446 (/ISS) Q5R8W5 (/ISS)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
8 A8DPD5 (/ISS) B5B850 (/ISS) B6RC74 (/ISS) F7EI59 (/ISS) Q2TJA4 (/ISS) Q5MYI7 (/ISS) Q5MYW5 (/ISS) Q5R8W5 (/ISS)
Cellular response to interferon-alpha GO:0035457
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
6 B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) F7EI55 (/ISS) F7I1U6 (/ISS) Q5R8W5 (/ISS)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
6 F1N3B8 (/ISS) F1N3B8 (/ISS) P29728 (/ISS) P29728 (/ISS) Q5MYU0 (/ISS) Q5MYU0 (/ISS)
Regulation of lactation GO:1903487
Any process that modulates the frequency, rate or extent of lactation.
6 F1N3B8 (/ISS) F1N3B8 (/ISS) P29728 (/ISS) P29728 (/ISS) Q5MYU0 (/ISS) Q5MYU0 (/ISS)
Purine nucleotide biosynthetic process GO:0006164
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
5 P11928 (/IDA) Q29599 (/IDA) Q80VT1 (/IDA) Q91YM7 (/IDA) Q9Z2F2 (/IDA)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
5 G3V645 (/ISS) Q5BKD0 (/ISS) Q5MYT7 (/ISS) Q8VI93 (/ISS) Q8VI94 (/ISS)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
5 P00973 (/IDA) Q15646 (/IDA) Q29599 (/IDA) Q60856 (/IDA) Q9Y6K5 (/IDA)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
5 E9Q9A9 (/IDA) E9Q9A9 (/IDA) Q15646 (/IDA) Q29599 (/IDA) Q9Y6K5 (/IDA)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
5 P00973 (/TAS) P29728 (/TAS) P29728 (/TAS) Q15646 (/TAS) Q9Y6K5 (/TAS)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
5 P00973 (/TAS) P29728 (/TAS) P29728 (/TAS) Q15646 (/TAS) Q9Y6K5 (/TAS)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
5 P00973 (/TAS) P29728 (/TAS) P29728 (/TAS) Q15646 (/TAS) Q9Y6K5 (/TAS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
4 P00973 (/IDA) Q15646 (/IDA) Q60856 (/IDA) Q9Y6K5 (/IDA)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
3 P29728 (/TAS) P29728 (/TAS) Q9Y6K5 (/TAS)
RNA catabolic process GO:0006401
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
2 E9Q9A9 (/IDA) E9Q9A9 (/IDA)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 Q8VI93 (/ISO) Q8VI94 (/ISO)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
2 E9Q9A9 (/IEP) E9Q9A9 (/IEP)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
2 Q8VI93 (/ISO) Q8VI94 (/ISO)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 Q8VI93 (/ISO) Q8VI94 (/ISO)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2 E9Q9A9 (/IDA) E9Q9A9 (/IDA)
Regulation of lactation GO:1903487
Any process that modulates the frequency, rate or extent of lactation.
2 E9Q9A9 (/IMP) E9Q9A9 (/IMP)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
1 P00973 (/IMP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 P00973 (/IMP)
Negative regulation of viral process GO:0048525
Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant.
1 P11928 (/IDA)
Regulation of ribonuclease activity GO:0060700
Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
1 Q9Y6K5 (/IDA)
Regulation of ribonuclease activity GO:0060700
Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
1 Q8VI93 (/ISO)

There are 27 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
18 A4LAA0 (/ISS) B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) B6RC68 (/ISS) B6RC73 (/ISS) B6RC74 (/ISS) F7EI55 (/ISS) F7EI59 (/ISS) F7I1U6 (/ISS)
(8 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 A0A087X0V5 (/IDA) A0A087X0V5 (/IDA) F8VXY3 (/IDA) H0YI20 (/IDA) P00973 (/IDA) P29728 (/IDA) P29728 (/IDA) Q15646 (/IDA) Q9Y6K5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 B5B850 (/ISS) B5B852 (/ISS) B6RC67 (/ISS) F7EI55 (/ISS) F7I1U6 (/ISS) Q5R8W5 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 A0A087X0V5 (/IDA) A0A087X0V5 (/IDA) P29728 (/IDA) P29728 (/IDA) Q15646 (/IDA) Q9Y6K5 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 E9Q9A9 (/ISO) E9Q9A9 (/ISO) P11928 (/ISO) Q8K469 (/ISO) Q8VI93 (/ISO) Q8VI94 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 E9Q9A9 (/ISO) E9Q9A9 (/ISO) P11928 (/ISO) Q8K469 (/ISO) Q8VI93 (/ISO) Q8VI94 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
6 E9Q9A9 (/ISS) E9Q9A9 (/ISS) F1N3B8 (/ISS) F1N3B8 (/ISS) Q5MYU0 (/ISS) Q5MYU0 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P00973 (/TAS) P29728 (/TAS) P29728 (/TAS) Q15646 (/TAS) Q9Y6K5 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 E9Q9A9 (/ISO) E9Q9A9 (/ISO) Q8VI93 (/ISO) Q8VI94 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q15646 (/IDA) Q29599 (/IDA) Q3ZM02 (/IDA) Q9Y6K5 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
4 A0A087X0V5 (/IDA) A0A087X0V5 (/IDA) P29728 (/IDA) P29728 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 P29728 (/HDA) P29728 (/HDA) Q15646 (/HDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
3 P29728 (/TAS) P29728 (/TAS) Q9Y6K5 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P11928 (/ISO) Q8K469 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 G3V645 (/ISS) Q8VI94 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P29728 (/TAS) P29728 (/TAS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 E9Q9A9 (/ISO) E9Q9A9 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 P29728 (/IDA) P29728 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 E9Q9A9 (/ISO) E9Q9A9 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9Y6K5 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q05961 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q15646 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q8VI94 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q60856 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q5BKD0 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9Y6K5 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8VI93 (/ISO)
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