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CATH Superfamily 1.10.1370.30

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Angiotensin-converting enzyme

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Angiotensin-converting enzyme 2. [EC: 3.4.17.23]
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine.
  • A transmembrane glycoprotein with an extracellular catalytic domain.
  • Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates.
  • Catalytic efficiency is 400-fold higher with angiotensin II (1-8) as a substrate than with angiotensin I (1-10).
  • Angiotensin-converting enzyme 2 also efficiently hydrolyzes des- Arg(9)-bradykinin, but it does not hydrolyze bradykinin.
  • Belongs to peptidase family M2.
 16 C7ECU5 C7ECU5 C7ECU6 C7ECU6 Q3URC9 Q3URC9 Q56H28 Q56NL1 Q56NL1 Q58DD0
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