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CATH Superfamily 1.10.1280.10

Di-copper center containing domain from catechol oxidase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Di-copper center containing domain from catechol oxidase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Polyphenol oxidase, chloroplastic

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Catechol oxidase. [EC: 1.10.3.1]
2 catechol + O(2) = 2 1,2-benzoquinone + 2 H(2)O.
  • A type 3 copper protein that catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones.
  • The enzyme also acts on a variety of substituted catechols.
  • It is different from tyrosinase, EC 1.14.18.1, which can catalyze both the monooxygenation of monophenols and the oxidation of catechols.
 2 O81103 Q9ZP19
(+)-larreatricin hydroxylase. [EC: 1.14.99.47]
(+)-larreatricin + O(2) + AH(2) = (+)-3'-hydroxylarreatricin + A + H(2)O.
  • Isolated from the plant Larrea tridentata (creosote bush).
  • The enzyme has a strong preference for the 3' position of (+)- larreatricin.
 1 Q6UIL3
Aureusidin synthase. [EC: 1.21.3.6]
(1) 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-glucoside + O(2) = aureusidin 6-O-beta-glucoside + H(2)O. (2) 2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-glucoside + O(2) = 2 aureusidin 6-O-beta-glucoside + 2 H(2)O. (3) 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-glucoside + O(2) = bracteatin 6-O-beta-glucoside + H(2)O.
  • Plays a key role in the yellow coloration of flowers such as Antirrhinum majus (snapdragon).
  • The enzyme is a homolog of plant polyphenol oxidase and catalyzes two separate chemical transformations, i.e. 3-hydroxylation and oxidative cyclization (2',-dehydrogenation).
  • H(2)O(2) activates reaction (1) but inhibits reaction (2).
  • Originally considered to act on the phenol but now thought to mainly act on the 4'-O-beta-glucoside in vivo.
 1 Q9FRX6
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