The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Large-conductance mechanosensitive channel, MscL; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Large-conductance mechanosensitive channel

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mechanosensitive ion channel activity GO:0008381
Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress.
113 P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA)
(103 more)
Mechanosensitive ion channel activity GO:0008381
Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress.
113 P0A742 (/IMP) P0A742 (/IMP) P0A742 (/IMP) P0A742 (/IMP) P0A742 (/IMP) P0A742 (/IMP) P0A742 (/IMP) P0A742 (/IMP) P0A742 (/IMP) P0A742 (/IMP)
(103 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
113 P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA)
(103 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
113 P0A742 (/IPI) P0A742 (/IPI) P0A742 (/IPI) P0A742 (/IPI) P0A742 (/IPI) P0A742 (/IPI) P0A742 (/IPI) P0A742 (/IPI) P0A742 (/IPI) P0A742 (/IPI)
(103 more)
Ion channel activity GO:0005216
Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
7 Q9KLX9 (/ISS) Q9KLX9 (/ISS) Q9KLX9 (/ISS) Q9KLX9 (/ISS) Q9KLX9 (/ISS) Q9KLX9 (/ISS) Q9KLX9 (/ISS)
Channel activity GO:0015267
Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
7 Q9KLX9 (/ISS) Q9KLX9 (/ISS) Q9KLX9 (/ISS) Q9KLX9 (/ISS) Q9KLX9 (/ISS) Q9KLX9 (/ISS) Q9KLX9 (/ISS)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
113 P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA)
(103 more)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
113 P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA)
(103 more)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
113 P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA)
(103 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
113 P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA)
(103 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
113 P0A742 (/HDA) P0A742 (/HDA) P0A742 (/HDA) P0A742 (/HDA) P0A742 (/HDA) P0A742 (/HDA) P0A742 (/HDA) P0A742 (/HDA) P0A742 (/HDA) P0A742 (/HDA)
(103 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
113 P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA) P0A742 (/IDA)
(103 more)
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