The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Glutathione Synthetase; Chain A, domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: Glutathione synthetase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 24 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
10 O22494 (/ISS) O23732 (/ISS) P35668 (/ISS) P35669 (/ISS) P46413 (/ISS) P51855 (/ISS) P51855 (/ISS) Q54E83 (/ISS) Q5EAC2 (/ISS) Q8HXX5 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
10 O22494 (/ISS) O23732 (/ISS) P35668 (/ISS) P35669 (/ISS) P46413 (/ISS) P51855 (/ISS) P51855 (/ISS) Q54E83 (/ISS) Q5EAC2 (/ISS) Q8HXX5 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
10 O22494 (/ISS) O23732 (/ISS) P35668 (/ISS) P35669 (/ISS) P46413 (/ISS) P51855 (/ISS) P51855 (/ISS) Q54E83 (/ISS) Q5EAC2 (/ISS) Q8HXX5 (/ISS)
Glutathione binding GO:0043295
Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
10 O22494 (/ISS) O23732 (/ISS) P35668 (/ISS) P35669 (/ISS) P46413 (/ISS) P51855 (/ISS) P51855 (/ISS) Q54E83 (/ISS) Q5EAC2 (/ISS) Q8HXX5 (/ISS)
Glutathione synthase activity GO:0004363
Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
5 P35669 (/IDA) P46413 (/IDA) P51855 (/IDA) P51855 (/IDA) Q7XB40 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P35669 (/IPI) P48637 (/IPI) P48637 (/IPI)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
3 P46413 (/IDA) P48637 (/IDA) P48637 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 P46413 (/IDA) P48637 (/IDA) P48637 (/IDA)
Glutathione binding GO:0043295
Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
3 P46413 (/IDA) P48637 (/IDA) P48637 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
2 P48637 (/IDA) P48637 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
2 P51855 (/ISO) P51855 (/ISO)
Glutathione synthase activity GO:0004363
Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
2 P51855 (/ISO) P51855 (/ISO)
Glutathione synthase activity GO:0004363
Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
2 P48637 (/TAS) P48637 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 P51855 (/ISO) P51855 (/ISO)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
2 P51855 (/ISO) P51855 (/ISO)
Peptide binding GO:0042277
Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.
2 P51855 (/ISO) P51855 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P48637 (/IPI) P48637 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P51855 (/ISO) P51855 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P51855 (/ISO) P51855 (/ISO)
Glutathione binding GO:0043295
Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.
2 P51855 (/ISO) P51855 (/ISO)
Glutathione synthase activity GO:0004363
Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
1 P35669 (/IMP)
Glutathione synthase activity GO:0004363
Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
1 Q54E83 (/ISS)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
1 P46413 (/IDA)
Peptide binding GO:0042277
Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.
1 P46413 (/IPI)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
3 P48637 (/TAS) P48637 (/TAS) Q7XB40 (/TAS)
Cellular amino acid metabolic process GO:0006520
The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
2 P48637 (/TAS) P48637 (/TAS)
Glutathione biosynthetic process GO:0006750
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
2 P35669 (/IDA) P46413 (/IDA)
Glutathione biosynthetic process GO:0006750
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
2 P51855 (/ISO) P51855 (/ISO)
Glutathione biosynthetic process GO:0006750
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
2 P48637 (/TAS) P48637 (/TAS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
2 P48637 (/TAS) P48637 (/TAS)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 P51855 (/IDA) P51855 (/IDA)
Glutathione biosynthetic process GO:0006750
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
1 P35669 (/IMP)
Glutathione biosynthetic process GO:0006750
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
1 Q54E83 (/ISS)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 P46413 (/IEP)
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
1 P46413 (/IEP)
Response to herbicide GO:0009635
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.
1 Q7XB40 (/IDA)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 P46413 (/IEP)
Response to tumor necrosis factor GO:0034612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 P46413 (/IEP)
Response to amino acid GO:0043200
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
1 P46413 (/IEP)
Phytochelatin biosynthetic process GO:0046938
The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11.
1 P35669 (/IMP)
Cellular response to cadmium ion GO:0071276
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 P35669 (/IMP)
Phytochelatin-metal complex formation GO:0090423
A phytochelatin metabolic process in which a metal is incorporated with phytochelatin to form a complex.
1 P35669 (/IMP)
Cellular detoxification of cadmium ion GO:0098849
Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration.
1 P35669 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P51855 (/ISO) P51855 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P48637 (/TAS) P48637 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P48637 (/HDA) P48637 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P35669 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P46413 (/IDA)
Glutathione synthase complex GO:0036087
A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer.
1 P35669 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...