The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: Homeobox A10

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 22 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
17 P17482 (/ISA) P28356 (/ISA) P28358 (/ISA) P28358 (/ISA) P28358 (/ISA) P28358 (/ISA) P28358 (/ISA) P28358 (/ISA) P31260 (/ISA) P31269 (/ISA)
(7 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
16 P17482 (/ISM) P28356 (/ISM) P28358 (/ISM) P28358 (/ISM) P28358 (/ISM) P28358 (/ISM) P28358 (/ISM) P28358 (/ISM) P31269 (/ISM) P31274 (/ISM)
(6 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
16 P17482 (/NAS) P28356 (/NAS) P28358 (/NAS) P28358 (/NAS) P28358 (/NAS) P28358 (/NAS) P28358 (/NAS) P28358 (/NAS) P31269 (/NAS) P31274 (/NAS)
(6 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 P09631 (/IPI) P17482 (/IPI) P28359 (/IPI) P31260 (/IPI) P31269 (/IPI) P31274 (/IPI) P31274 (/IPI) P31274 (/IPI) P31274 (/IPI) P31274 (/IPI)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
4 P28356 (/IDA) P28359 (/IDA) Q9NYD6 (/IDA) Q9NYD6 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P28359 (/IDA) P31260 (/IDA) Q9NYD6 (/IDA) Q9NYD6 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
2 P28357 (/ISO) P31257 (/ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 P31257 (/ISO) P31310 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P28357 (/IDA) P28359 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 P28357 (/IDA) P28359 (/IDA)
Showing 1 to 10 of 22 entries

There are 50 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
51 P09631 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI)
(41 more)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
48 P09631 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP)
(38 more)
Embryonic skeletal system development GO:0048706
The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.
48 P09631 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI) P09633 (/IGI)
(38 more)
Embryonic skeletal system morphogenesis GO:0048704
The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
44 P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP) P09633 (/IMP)
(34 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
8 P09631 (/IDA) P20615 (/IDA) P20615 (/IDA) P28357 (/IDA) P28359 (/IDA) P31260 (/IDA) Q9NYD6 (/IDA) Q9NYD6 (/IDA)
Proximal/distal pattern formation GO:0009954
The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).
5 P09631 (/IGI) P28357 (/IGI) P28359 (/IGI) P31257 (/IGI) P31310 (/IGI)
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
4 P09631 (/IGI) P28357 (/IGI) P28359 (/IGI) P31310 (/IGI)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
4 P09631 (/IGI) P28357 (/IGI) P28359 (/IGI) P31310 (/IGI)
Mammary gland development GO:0030879
The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.
4 P09631 (/IGI) P20615 (/IGI) P20615 (/IGI) P28357 (/IGI)
Embryonic skeletal system development GO:0048706
The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.
4 P09631 (/IMP) P20615 (/IMP) P20615 (/IMP) P28357 (/IMP)
Showing 1 to 10 of 50 entries

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
48 P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO)
(38 more)
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
44 P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO) P09633 (/ISO)
(34 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
21 A0A024RAZ6 (/IDA) A0A024RAZ6 (/IDA) A0A024RAZ6 (/IDA) A0A024RAZ6 (/IDA) A0A024RAZ6 (/IDA) P17482 (/IDA) P28358 (/IDA) P28358 (/IDA) P28358 (/IDA) P28358 (/IDA)
(11 more)
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
10 A0A024RAZ6 (/IDA) A0A024RAZ6 (/IDA) A0A024RAZ6 (/IDA) A0A024RAZ6 (/IDA) A0A024RAZ6 (/IDA) P31274 (/IDA) P31274 (/IDA) P31274 (/IDA) P31274 (/IDA) P31274 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P28358 (/IDA) P28358 (/IDA) P28358 (/IDA) P28358 (/IDA) P28358 (/IDA) P28358 (/IDA)
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
6 P28358 (/IDA) P28358 (/IDA) P28358 (/IDA) P28358 (/IDA) P28358 (/IDA) P28358 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P28356 (/IDA) P28357 (/IDA) P31260 (/IDA) P31269 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
4 Q53XI4 (/IDA) Q53XI4 (/IDA) Q9NYD6 (/IDA) Q9NYD6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P09631 (/ISO) P28357 (/ISO) P31310 (/ISO)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
2 P09631 (/IDA) P31310 (/IDA)
Showing 1 to 10 of 22 entries
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