The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Phosphatase 2C, C-terminal domain suprefamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Protein phosphatase, Mg2+/Mn2+ dependent 1A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
15 P20650 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI)
(5 more)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
14 P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA)
(4 more)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
14 P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS)
(4 more)
Calmodulin-dependent protein phosphatase activity GO:0033192
Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.
14 P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA)
(4 more)
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
14 P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI) P35813 (/IPI)
(4 more)
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
5 O62829 (/ISS) O62829 (/ISS) P20650 (/ISS) P35814 (/ISS) P49443 (/ISS)
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
3 O62829 (/ISS) O62829 (/ISS) P35814 (/ISS)
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
1 P49443 (/IDA)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
1 P49443 (/ISO)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P20650 (/IPI)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P49443 (/ISO)
Calmodulin-dependent protein phosphatase activity GO:0033192
Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.
1 P49443 (/ISO)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 P20650 (/IDA)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 P49443 (/ISO)
R-SMAD binding GO:0070412
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein.
1 P49443 (/ISO)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
N-terminal protein myristoylation GO:0006499
The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.
18 O62829 (/ISS) O62829 (/ISS) P20650 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS)
(8 more)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
15 P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP)
(5 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
14 P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS)
(4 more)
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
14 P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS)
(4 more)
Negative regulation of SMAD protein complex assembly GO:0010991
Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins.
14 P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA)
(4 more)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
14 P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA)
(4 more)
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
14 P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA)
(4 more)
Peptidyl-threonine dephosphorylation GO:0035970
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
14 P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA)
(4 more)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
14 P35813 (/HMP) P35813 (/HMP) P35813 (/HMP) P35813 (/HMP) P35813 (/HMP) P35813 (/HMP) P35813 (/HMP) P35813 (/HMP) P35813 (/HMP) P35813 (/HMP)
(4 more)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
14 P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP)
(4 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
14 P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA)
(4 more)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
14 P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA)
(4 more)
Negative regulation of NIK/NF-kappaB signaling GO:1901223
Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.
14 P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP) P35813 (/IMP)
(4 more)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
5 O62829 (/ISS) O62829 (/ISS) P20650 (/ISS) P35814 (/ISS) P49443 (/ISS)
Negative regulation of NIK/NF-kappaB signaling GO:1901223
Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.
5 O62829 (/ISS) O62829 (/ISS) P20650 (/ISS) P35814 (/ISS) P49443 (/ISS)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
4 O62829 (/ISS) O62829 (/ISS) P20650 (/ISS) P35814 (/ISS)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
3 O62829 (/ISS) O62829 (/ISS) P35814 (/ISS)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 P49443 (/IDA)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 P49443 (/ISO)
N-terminal protein myristoylation GO:0006499
The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.
1 P49443 (/IDA)
Negative regulation of SMAD protein complex assembly GO:0010991
Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins.
1 P49443 (/ISO)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
1 P49443 (/ISO)
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
1 P49443 (/ISO)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
1 P49443 (/IMP)
Peptidyl-threonine dephosphorylation GO:0035970
The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
1 P49443 (/ISO)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
1 P49443 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P49443 (/ISO)
Positive regulation of protein export from nucleus GO:0046827
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.
1 P49443 (/IMP)
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
1 P49443 (/IDA)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 P49443 (/ISO)
Negative regulation of NIK/NF-kappaB signaling GO:1901223
Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.
1 P49443 (/ISO)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
29 A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA)
(19 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
28 A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA) A0A024R6A5 (/IDA)
(18 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
18 O62829 (/ISS) O62829 (/ISS) P20650 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS)
(8 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
18 O62829 (/ISS) O62829 (/ISS) P20650 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS) P35813 (/ISS)
(8 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
15 P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA) P35813 (/IDA)
(5 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
14 P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS)
(4 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
14 P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS) P35813 (/TAS)
(4 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P49443 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P49443 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P49443 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P49443 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P20650 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P49443 (/ISO)
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