The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Telomeric repeat-binding factor 2-interacting prot...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9NYB0 (/IPI)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
1 Q9NYB0 (/IPI)
Telomeric DNA binding GO:0042162
Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.
1 Q9NYB0 (/IDA)
G-rich strand telomeric DNA binding GO:0098505
Interacting selectively and non-covalently with G-rich, single-stranded, telomere-associated DNA.
1 Q9NYB0 (/IDA)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
14 B8QB46 (/ISS) D2HY19 (/ISS) Q0VCT3 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS)
(4 more)
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
14 B8QB46 (/ISS) D2HY19 (/ISS) Q0VCT3 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS)
(4 more)
Telomere maintenance via telomere lengthening GO:0010833
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA.
14 B8QB46 (/ISS) D2HY19 (/ISS) Q0VCT3 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS)
(4 more)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
14 B8QB46 (/ISS) D2HY19 (/ISS) Q0VCT3 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS)
(4 more)
Negative regulation of DNA recombination at telomere GO:0048239
Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere.
14 B8QB46 (/ISS) D2HY19 (/ISS) Q0VCT3 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS)
(4 more)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
14 B8QB46 (/ISS) D2HY19 (/ISS) Q0VCT3 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS)
(4 more)
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
1 Q9NYB0 (/IDA)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 Q9NYB0 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9NYB0 (/IMP)
Telomere maintenance via telomerase GO:0007004
The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.
1 Q9NYB0 (/TAS)
Telomere capping GO:0016233
A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins.
1 Q9NYB0 (/TAS)
Protection from non-homologous end joining at telomere GO:0031848
A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse.
1 Q9NYB0 (/IMP)
Regulation of telomere maintenance GO:0032204
Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
1 Q9NYB0 (/IMP)
Negative regulation of telomere maintenance GO:0032205
Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
1 Q9NYB0 (/IDA)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
1 Q9NYB0 (/IMP)
Protein localization to chromosome, telomeric region GO:0070198
Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome.
1 Q9NYB0 (/IMP)
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
1 Q9NYB0 (/IMP)
Positive regulation of protein acetylation GO:1901985
Any process that activates or increases the frequency, rate or extent of protein acetylation.
1 Q9NYB0 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromosome, telomeric region GO:0000781
The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.
14 B8QB46 (/ISS) D2HY19 (/ISS) Q0VCT3 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS)
(4 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
14 B8QB46 (/ISS) D2HY19 (/ISS) Q0VCT3 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS)
(4 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
14 B8QB46 (/ISS) D2HY19 (/ISS) Q0VCT3 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS) Q4R4I0 (/ISS)
(4 more)
Nuclear chromosome GO:0000228
A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
1 Q9NYB0 (/TAS)
Chromosome, telomeric region GO:0000781
The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.
1 Q9NYB0 (/IDA)
Nuclear telomere cap complex GO:0000783
A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome.
1 Q9NYB0 (/IDA)
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
1 Q9NYB0 (/HDA)
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
1 Q9NYB0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9NYB0 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9NYB0 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9NYB0 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9NYB0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9NYB0 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q9NYB0 (/IDA)
Shelterin complex GO:0070187
A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1.
1 Q9NYB0 (/IDA)
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