The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"IrrE, HTH domain
".
1.10.10.1030
superfamily
Functional Families
Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
Superfamily: IrrE, HTH domain
This superfamily entry represents the HTH (helix-turn-helix) central domain from the metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae PMID:19150362. It is folded in a three-helix bundle, with the second and third helices forming the HTH motif. The IrrE HTH domain shows a high level of structural similarity to HTH domains of the Lrp/AsnC transcriptional regulatory family, although it is not located as expected at either C- or N- termini of the protein. Its central location (residues 126-167) was suggested to endow it with some specific properties PMID:19150362.
This domain is also found in HTH-type transcriptional regulators RamB PMID:15090522 and PrpC PMID:22916289. The entry also includes the catalytic domain of the protein ImmA (MEROPS identifier M78.001), a metallopeptidase containing an HEXXH zinc-binding motif.
GO Diversity
Unique GO annotations
0 Unique GO terms
EC Diversity
Unique EC annotations
0 Unique EC terms
Species Diversity
Unique species annotations
23 Unique species
Sequence/Structure Diversity
Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.
Superfamily Summary
A general summary of information for this superfamily.
| Structures | |
|---|---|
| Domains: | 3 |
| Domain clusters (>95% seq id): | 1 |
| Domain clusters (>35% seq id): | 1 |
| Unique PDBs: | 3 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 0 |
| Function | |
| Unique EC: | |
| Unique GO: | |
| Taxonomy | |
| Unique Species: | 23 |
