The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 75: Histone H1 like

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 26 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
20 P02253 (/IPI) P02253 (/IPI) P10412 (/IPI) P10412 (/IPI) P10412 (/IPI) P10412 (/IPI) P15864 (/IPI) P15864 (/IPI) P16401 (/IPI) P16401 (/IPI)
(10 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
10 P10412 (/HDA) P10412 (/HDA) P10412 (/HDA) P10412 (/HDA) P16401 (/HDA) P16401 (/HDA) P16401 (/HDA) P16402 (/HDA) P16403 (/HDA) P16403 (/HDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
9 P15864 (/IDA) P15864 (/IDA) P43274 (/IDA) P43275 (/IDA) P43275 (/IDA) P43276 (/IDA) P43277 (/IDA) P43277 (/IDA) Q07133 (/IDA)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
8 P10412 (/IMP) P10412 (/IMP) P10412 (/IMP) P10412 (/IMP) P16401 (/IMP) P16401 (/IMP) P16401 (/IMP) Q02539 (/IMP)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
4 P15864 (/ISO) P15864 (/ISO) P43277 (/ISO) P43277 (/ISO)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
3 P16402 (/IDA) P16403 (/IDA) P16403 (/IDA)
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
3 P16401 (/IPI) P16401 (/IPI) P16401 (/IPI)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2 P43275 (/IDA) P43275 (/IDA)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
1 P15865 (/IDA)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
1 P43274 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 A5PK20 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 P15865 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 Q07133 (/IMP)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 P43274 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 P15865 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 P43274 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P15865 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P43274 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 P15865 (/IDA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 P43274 (/ISO)
AMP binding GO:0016208
Interacting selectively and non-covalently with AMP, adenosine monophosphate.
1 P15865 (/IDA)
AMP binding GO:0016208
Interacting selectively and non-covalently with AMP, adenosine monophosphate.
1 P43274 (/ISO)
DATP binding GO:0032564
Interacting selectively and non-covalently with dATP, deoxyadenosine triphosphate.
1 P15865 (/IDA)
DATP binding GO:0032564
Interacting selectively and non-covalently with dATP, deoxyadenosine triphosphate.
1 P43274 (/ISO)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
1 P15865 (/IDA)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
1 P43274 (/ISO)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
5 P15864 (/IGI) P15864 (/IGI) P43274 (/IGI) P43277 (/IGI) P43277 (/IGI)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
5 P15864 (/IMP) P15864 (/IMP) P43274 (/IMP) P43277 (/IMP) P43277 (/IMP)
Nucleosome positioning GO:0016584
Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another.
5 P15864 (/IMP) P15864 (/IMP) P43274 (/IMP) P43277 (/IMP) P43277 (/IMP)
Histone H3-K4 trimethylation GO:0080182
The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.
5 P15864 (/IGI) P15864 (/IGI) P43274 (/IGI) P43277 (/IGI) P43277 (/IGI)
Histone H3-K27 trimethylation GO:0098532
The modification of histone H3 by addition of three methyl groups to lysine at position 27 of the histone.
5 P15864 (/IGI) P15864 (/IGI) P43274 (/IGI) P43277 (/IGI) P43277 (/IGI)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 P16401 (/IMP) P16401 (/IMP) P16401 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
3 P16401 (/IMP) P16401 (/IMP) P16401 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
3 P43275 (/IGI) P43275 (/IGI) Q07133 (/IGI)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
3 P16401 (/IMP) P16401 (/IMP) P16401 (/IMP)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
3 P16401 (/IMP) P16401 (/IMP) P16401 (/IMP)
Positive regulation of histone H3-K9 methylation GO:0051574
Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.
3 P16401 (/IMP) P16401 (/IMP) P16401 (/IMP)
Establishment of protein localization to chromatin GO:0071169
The directed movement of a protein to a part of a chromosome that is organized into chromatin.
3 P16401 (/IMP) P16401 (/IMP) P16401 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 P22492 (/TAS) Q02539 (/TAS)
Positive regulation of receptor-mediated endocytosis GO:0048260
Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
2 P43275 (/IDA) P43275 (/IDA)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 P06349 (/IEP)
Binding of sperm to zona pellucida GO:0007339
The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.
1 Q07133 (/IGI)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 P43276 (/IPI)
Chromosome condensation GO:0030261
The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
1 P15865 (/TAS)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 Q07133 (/IGI)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
13 P06350 (/IDA) P10412 (/IDA) P10412 (/IDA) P10412 (/IDA) P10412 (/IDA) P16401 (/IDA) P16401 (/IDA) P16401 (/IDA) P16403 (/IDA) P16403 (/IDA)
(3 more)
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
7 P10412 (/IDA) P10412 (/IDA) P10412 (/IDA) P10412 (/IDA) P16401 (/IDA) P16401 (/IDA) P16401 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
6 A5PK20 (/IDA) P16401 (/IDA) P16401 (/IDA) P16401 (/IDA) P16402 (/IDA) Q02539 (/IDA)
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
4 P16402 (/IDA) P16403 (/IDA) P16403 (/IDA) Q02539 (/IDA)
Nuclear euchromatin GO:0005719
The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.
4 P15864 (/ISO) P15864 (/ISO) P43277 (/ISO) P43277 (/ISO)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
2 P43277 (/ISO) P43277 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P15864 (/ISO) P15864 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 P43275 (/IDA) P43275 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
2 P43275 (/IDA) P43275 (/IDA)
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
2 P15864 (/IDA) P15864 (/IDA)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 P15865 (/TAS)
Nuclear nucleosome GO:0000788
A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures.
1 P15865 (/IDA)
Nuclear nucleosome GO:0000788
A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures.
1 P43274 (/ISO)
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
1 Q07133 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P22492 (/HDA)
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