CATH Superfamily 1.10.10.10
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".
FunFam 32: Forkhead box protein O4
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 59 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
16 |
A0A096MJF0 (/IPI)
A8MYZ6 (/IPI)
B3DGQ4 (/IPI)
D4A433 (/IPI)
O16850 (/IPI)
O43524 (/IPI)
P98177 (/IPI)
Q12778 (/IPI)
Q12778 (/IPI)
Q5TYS1 (/IPI)
(6 more) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
13 |
B3LYS5 (/ISS)
B3P0K6 (/ISS)
B4G4S8 (/ISS)
B4HF64 (/ISS)
B4JSC2 (/ISS)
B4KBF6 (/ISS)
B4MB78 (/ISS)
B4NFR1 (/ISS)
B4PTD3 (/ISS)
Q298W7 (/ISS)
(3 more) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
10 | G3V7R4 (/IDA) O16850 (/IDA) O43524 (/IDA) P98177 (/IDA) Q12778 (/IDA) Q12778 (/IDA) Q9R1E0 (/IDA) Q9WVH3 (/IDA) Q9WVH3 (/IDA) Q9WVH4 (/IDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
9 | A4L7N3 (/ISS) E1BPQ1 (/ISS) G3V7R4 (/ISS) Q66JJ0 (/ISS) Q6EUW1 (/ISS) Q6EUW2 (/ISS) Q810W5 (/ISS) Q9R1E0 (/ISS) Q9WVH5 (/ISS) |
|
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
|
7 | A4L7N3 (/ISS) E1BPQ1 (/ISS) G3V7R4 (/ISS) Q12778 (/ISS) Q12778 (/ISS) Q810W5 (/ISS) Q9WVH5 (/ISS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
6 | G3V7R4 (/IDA) O16850 (/IDA) O43524 (/IDA) P98177 (/IDA) Q9R1E0 (/IDA) Q9WVH4 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
5 | A8MYZ6 (/ISA) O43524 (/ISA) P98177 (/ISA) Q12778 (/ISA) Q12778 (/ISA) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
5 | Q12778 (/ISS) Q12778 (/ISS) Q66JJ0 (/ISS) Q6EUW2 (/ISS) Q810W5 (/ISS) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
4 | O43524 (/ISM) P98177 (/ISM) Q12778 (/ISM) Q12778 (/ISM) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | O43524 (/IDA) P98177 (/IDA) Q9R1E0 (/IDA) Q9WVH4 (/IDA) |
Showing 1 to 10 of 59 entries
There are 256 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
12 |
B3LYS5 (/ISS)
B3P0K6 (/ISS)
B4G4S8 (/ISS)
B4HF64 (/ISS)
B4JSC2 (/ISS)
B4KBF6 (/ISS)
B4MB78 (/ISS)
B4NFR1 (/ISS)
B4PTD3 (/ISS)
Q298W7 (/ISS)
(2 more) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
12 |
B3LYS5 (/ISS)
B3P0K6 (/ISS)
B4G4S8 (/ISS)
B4HF64 (/ISS)
B4JSC2 (/ISS)
B4KBF6 (/ISS)
B4MB78 (/ISS)
B4NFR1 (/ISS)
B4PTD3 (/ISS)
Q298W7 (/ISS)
(2 more) |
|
Multicellular organism aging GO:0010259
An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).
|
10 | B3LYS5 (/ISS) B3P0K6 (/ISS) B4G4S8 (/ISS) B4HF64 (/ISS) B4JSC2 (/ISS) B4KBF6 (/ISS) B4MB78 (/ISS) B4NFR1 (/ISS) B4PTD3 (/ISS) Q298W7 (/ISS) |
|
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
10 | B3LYS5 (/ISS) B3P0K6 (/ISS) B4G4S8 (/ISS) B4HF64 (/ISS) B4JSC2 (/ISS) B4KBF6 (/ISS) B4MB78 (/ISS) B4NFR1 (/ISS) B4PTD3 (/ISS) Q298W7 (/ISS) |
|
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
10 | B3LYS5 (/ISS) B3P0K6 (/ISS) B4G4S8 (/ISS) B4HF64 (/ISS) B4JSC2 (/ISS) B4KBF6 (/ISS) B4MB78 (/ISS) B4NFR1 (/ISS) B4PTD3 (/ISS) Q298W7 (/ISS) |
|
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
10 | B3LYS5 (/ISS) B3P0K6 (/ISS) B4G4S8 (/ISS) B4HF64 (/ISS) B4JSC2 (/ISS) B4KBF6 (/ISS) B4MB78 (/ISS) B4NFR1 (/ISS) B4PTD3 (/ISS) Q298W7 (/ISS) |
|
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
|
10 | B3LYS5 (/ISS) B3P0K6 (/ISS) B4G4S8 (/ISS) B4HF64 (/ISS) B4JSC2 (/ISS) B4KBF6 (/ISS) B4MB78 (/ISS) B4NFR1 (/ISS) B4PTD3 (/ISS) Q298W7 (/ISS) |
|
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
|
9 | A4L7N3 (/ISS) E1BPQ1 (/ISS) G3V7R4 (/ISS) Q12778 (/ISS) Q12778 (/ISS) Q66JJ0 (/ISS) Q6EUW2 (/ISS) Q810W5 (/ISS) Q9R1E0 (/ISS) |
|
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
9 | A4L7N3 (/ISS) E1BPQ1 (/ISS) G3V7R4 (/ISS) O43524 (/ISS) Q66JJ0 (/ISS) Q6EUW1 (/ISS) Q6EUW2 (/ISS) Q810W5 (/ISS) Q9R1E0 (/ISS) |
|
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
9 | A4L7N3 (/ISS) E1BPQ1 (/ISS) G3V7R4 (/ISS) O43524 (/ISS) Q12778 (/ISS) Q12778 (/ISS) Q6EUW1 (/ISS) Q810W5 (/ISS) Q9WVH5 (/ISS) |
Showing 1 to 10 of 256 entries
There are 26 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
20 |
A4L7N3 (/ISS)
A8MYZ6 (/ISS)
B3LYS5 (/ISS)
B3P0K6 (/ISS)
B4G4S8 (/ISS)
B4HF64 (/ISS)
B4JSC2 (/ISS)
B4KBF6 (/ISS)
B4MB78 (/ISS)
B4NFR1 (/ISS)
(10 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
20 |
A4L7N3 (/ISS)
A8MYZ6 (/ISS)
B3LYS5 (/ISS)
B3P0K6 (/ISS)
B4G4S8 (/ISS)
B4HF64 (/ISS)
B4JSC2 (/ISS)
B4KBF6 (/ISS)
B4MB78 (/ISS)
B4NFR1 (/ISS)
(10 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
17 |
A0A096MJF0 (/IDA)
A0A096MJN1 (/IDA)
A4L7N3 (/IDA)
B3G3K1 (/IDA)
D3ZBQ1 (/IDA)
D4A433 (/IDA)
F1RME6 (/IDA)
G3V7R4 (/IDA)
O16850 (/IDA)
O43524 (/IDA)
(7 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
17 |
A0A096MJF0 (/IDA)
A4L7N3 (/IDA)
B3G3K1 (/IDA)
D3ZBQ1 (/IDA)
D4A433 (/IDA)
F1NNE8 (/IDA)
F1RME6 (/IDA)
G3V7R4 (/IDA)
O16850 (/IDA)
O43524 (/IDA)
(7 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
11 |
D3ZBQ1 (/TAS)
G3V7R4 (/TAS)
O43524 (/TAS)
P98177 (/TAS)
Q12778 (/TAS)
Q12778 (/TAS)
Q70KY4 (/TAS)
Q9R1E0 (/TAS)
Q9WVH3 (/TAS)
Q9WVH3 (/TAS)
(1 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
10 | A0A096MJF0 (/IDA) A0A096MJN1 (/IDA) D3ZBQ1 (/IDA) D4A433 (/IDA) G3V7R4 (/IDA) O16850 (/IDA) O43524 (/IDA) P98177 (/IDA) Q95V55 (/IDA) Q9WVH4 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
8 | Q12778 (/ISS) Q12778 (/ISS) Q66JJ0 (/ISS) Q6EUW1 (/ISS) Q6EUW2 (/ISS) Q810W5 (/ISS) Q9WVH3 (/ISS) Q9WVH3 (/ISS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
5 | Q12778 (/ISS) Q12778 (/ISS) Q66JJ0 (/ISS) Q6EUW2 (/ISS) Q810W5 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | O43524 (/TAS) P98177 (/TAS) Q12778 (/TAS) Q12778 (/TAS) Q95V55 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q9R1E0 (/ISO) Q9WVH3 (/ISO) Q9WVH3 (/ISO) Q9WVH4 (/ISO) |
Showing 1 to 10 of 26 entries
