CATH Domain 6qm8b00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.20	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
	3.60.20.10	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1

Domain Context

CATH Clusters

Superfamily	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Functional Family	Proteasome subunit beta

Enzyme Information

UniProtKB Entries (1)

A4I357_LEIIN

Leishmania infantum

Proteasome endopeptidase complex

PDB Structure

PDB	6QM8
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition. Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C.W., Pena, I., Bingham, R.P., Bueren-Calabuig, J.A., Cantizani, J., Cebrian, D., Craggs, P.D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E.J., Korczynska, J., MacLean, L., Manthri, S., Martinez, M.S., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F.R.C., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R.J., Zuccotto, F., Horn, D., Ferguson, M.A.J., Fairlamb, A.H., Fiandor, J.M., Martin, J., Gray, D.W., Miles, T.J., Gilbert, I.H., Read, K.D., Marco, M., Wyatt, P.G. Proc.Natl.Acad.Sci.USA