CATH Domain 6hskB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.800	Arginase; Chain A
	3.40.800.20	Histone deacetylase domain

Domain Context

CATH Clusters

Superfamily	Histone deacetylase domain
Functional Family	Histone deacetylase 8

Enzyme Information

3.5.1.98

Histone deacetylase.

based on mapping to UniProt Q9BY41

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC 2.3.1.48. -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC 3.5.1.17.

UniProtKB Entries (1)

Q9BY41

HDAC8_HUMAN

Homo sapiens

Histone deacetylase 8

PDB Structure

PDB	6HSK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. Marek, M., Shaik, T.B., Heimburg, T., Chakrabarti, A., Lancelot, J., Ramos-Morales, E., Da Veiga, C., Kalinin, D., Melesina, J., Robaa, D., Schmidtkunz, K., Suzuki, T., Holl, R., Ennifar, E., Pierce, R.J., Jung, M., Sippl, W., Romier, C. J. Med. Chem.