CATH Classification

Domain Context

CATH Clusters

Superfamily Diphthamide synthesis DPH1/DPH2 domain 3
Functional Family 2-(3-amino-3-carboxypropyl)histidine synthase

Enzyme Information

2.5.1.108
2-(3-amino-3-carboxypropyl)histidine synthase.
based on mapping to UniProt O58832
L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine.
-!- Modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical. -!- The enzyme is present in archae and eukaryotes but not in eubacteria. -!- Part of diphthamide biosynthesis. -!- Formerly EC 2.5.1.n7.

UniProtKB Entries (1)

O58832
DPH2_PYRHO
Pyrococcus horikoshii OT3
2-(3-amino-3-carboxypropyl)histidine synthase

PDB Structure

PDB 6BXK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
Dong, M., Kathiresan, V., Fenwick, M.K., Torelli, A.T., Zhang, Y., Caranto, J.D., Dzikovski, B., Sharma, A., Lancaster, K.M., Freed, J.H., Ealick, S.E., Hoffman, B.M., Lin, H.
Science
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