CATH Domain 6bm7D00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.90	S-adenosylmethionine decarboxylase
	3.60.90.10	S-adenosylmethionine decarboxylase

Domain Context

CATH Clusters

Superfamily	S-adenosylmethionine decarboxylase
Functional Family	S-adenosylmethionine decarboxylase proenzyme

Enzyme Information

4.1.1.50

Adenosylmethionine decarboxylase.

based on mapping to UniProt Q587A7

S-adenosyl-L-methionine = S-adenosyl 3-(methylthio)propylamine + CO(2).

UniProtKB Entries (2)

Q587A7	Q587A7_TRYB2 Trypanosoma brucei brucei TREU927 S-adenosylmethionine decarboxylase proenzyme
A5HNV6	DCAMP_TRYBB Trypanosoma brucei brucei Inactive S-adenosylmethionine decarboxylase prozyme

PDB Structure

PDB	6BM7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase. Volkov, O.A., Brockway, A.J., Wring, S.A., Peel, M., Chen, Z., Phillips, M.A., De Brabander, J.K. J. Med. Chem.