CATH Domain 6arkA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	KRAS proto-oncogene, GTPase

Enzyme Information

UniProtKB Entries (1)

RASK_HUMAN

Homo sapiens

GTPase KRas

PDB Structure

PDB	6ARK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange. Nnadi, C.I., Jenkins, M.L., Gentile, D.R., Bateman, L.A., Zaidman, D., Balius, T.E., Nomura, D.K., Burke, J.E., Shokat, K.M., London, N. J Chem Inf Model