CATH Domain 5z86N00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.210	Cytochrome C Oxidase; Chain A
	1.20.210.10	Cytochrome c oxidase-like, subunit I domain

Domain Context

CATH Clusters

Superfamily	Cytochrome c oxidase-like, subunit I domain
Functional Family	Cytochrome c oxidase subunit 1

Enzyme Information

1.9.3.1

Cytochrome-c oxidase.

based on mapping to UniProt P00396

4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.

-!- The reduction of O(2) to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. -!- Several bacteria appear to contain analogous oxidases.

UniProtKB Entries (1)

P07471

CX6A2_BOVIN

Bos taurus

Cytochrome c oxidase subunit 6A2, mitochondrial

PDB Structure

PDB	5Z86
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	X-ray structural analyses of azide-bound cytochromecoxidases reveal that the H-pathway is critically important for the proton-pumping activity. Shimada, A., Hatano, K., Tadehara, H., Yano, N., Shinzawa-Itoh, K., Yamashita, E., Muramoto, K., Tsukihara, T., Yoshikawa, S. J. Biol. Chem.