CATH Domain 5vfcA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.10	YVTN repeat-like/Quinoprotein amine dehydrogenase

Domain Context

CATH Clusters

Superfamily	YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family	WD repeat-containing protein 5

Enzyme Information

UniProtKB Entries (1)

WDR5_HUMAN

Homo sapiens

WD repeat-containing protein 5

PDB Structure

PDB	5VFC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. Karatas, H., Li, Y., Liu, L., Ji, J., Lee, S., Chen, Y., Yang, J., Huang, L., Bernard, D., Xu, J., Townsend, E.C., Cao, F., Ran, X., Li, X., Wen, B., Sun, D., Stuckey, J.A., Lei, M., Dou, Y., Wang, S. J. Med. Chem.