CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.990 | NADPH-cytochrome p450 Reductase; Chain A, domain 3 |
|
1.20.990.10 | NADPH-cytochrome p450 Reductase; Chain A, domain 3 |
Domain Context
CATH Clusters
| Superfamily | NADPH-cytochrome p450 Reductase; Chain A, domain 3 |
| Functional Family | NADPH--cytochrome P450 reductase |
Enzyme Information
| 1.6.2.4 |
NADPH--hemoprotein reductase.
based on mapping to UniProt P00388
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
-!- This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. -!- It also reduces cytochrome b5 and cytochrome c. -!- The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
|
UniProtKB Entries (1)
| P00388 |
NCPR_RAT
Rattus norvegicus
NADPH--cytochrome P450 reductase
|
PDB Structure
| PDB | 5URH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH Binding and Hydride Transfer.
Biochemistry
|
