CATH Domain 5ughB02

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.300	GMP Synthetase; Chain A, domain 3
	3.30.300.10

Superfamily	3.30.300.10
Functional Family

2.5.1.6

Methionine adenosyltransferase.

based on mapping to UniProt P31153

ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L- methionine.

-!- Formerly EC 2.4.2.13.

METK2_HUMAN

Homo sapiens

S-adenosylmethionine synthase isoform type-2

PDB	5UGH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. Quinlan, C.L., Kaiser, S.E., Bolanos, B., Nowlin, D., Grantner, R., Karlicek-Bryant, S., Feng, J.L., Jenkinson, S., Freeman-Cook, K., Dann, S.G., Wang, X., Wells, P.A., Fantin, V.R., Stewart, A.E., Grant, S.K. Nat. Chem. Biol.