CATH Domain 5th7A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.270	Beta-clip-like
	2.170.270.10	SET domain

Domain Context

CATH Clusters

Superfamily	SET domain
Functional Family	Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q9NQR1 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
2.1.1.-	Methyltransferases. based on mapping to UniProt Q9NQR1

UniProtKB Entries (1)

KMT5A_HUMAN

Homo sapiens

N-lysine methyltransferase KMT5A

PDB Structure

PDB	5TH7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. Butler, K.V., Ma, A., Yu, W., Li, F., Tempel, W., Babault, N., Pittella-Silva, F., Shao, J., Wang, J., Luo, M., Vedadi, M., Brown, P.J., Arrowsmith, C.H., Jin, J. J. Med. Chem.