CATH Domain 5l0kA04

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.570	Extracellular Endonuclease; Chain A
	3.40.570.10	Extracellular Endonuclease, subunit A

Superfamily	Extracellular Endonuclease, subunit A
Functional Family	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

3.1.4.39

Alkylglycerophosphoethanolamine phosphodiesterase.

based on mapping to UniProt Q64610

1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine.

-!- Also acts on acyl and choline analogs.

ENPP2_RAT

Rattus norvegicus

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

PDB	5L0K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design. Jones, S.B., Pfeifer, L.A., Bleisch, T.J., Beauchamp, T.J., Durbin, J.D., Klimkowski, V.J., Hughes, N.E., Rito, C.J., Dao, Y., Gruber, J.M., Bui, H., Chambers, M.G., Chandrasekhar, S., Lin, C., McCann, D.J., Mudra, D.R., Oskins, J.L., Swearingen, C.A., Thirunavukkarasu, K., Norman, B.H. Acs Med.Chem.Lett.