CATH Domain 5gsaA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.10	YVTN repeat-like/Quinoprotein amine dehydrogenase

Domain Context

CATH Clusters

Superfamily	YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family	Polycomb protein eed

Enzyme Information

UniProtKB Entries (1)

EED_HUMAN

Homo sapiens

Polycomb protein EED

PDB Structure

PDB	5GSA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of Qi, W., Zhao, K., Gu, J., Huang, Y., Wang, Y., Zhang, H., Zhang, M., Zhang, J., Yu, Z., Li, L., Teng, L., Chuai, S., Zhang, C., Zhao, M., Chan, H., Chen, Z., Fang, D., Fei, Q., Feng, L., Feng, L., Gao, Y., Ge, H., Ge, X., Li, G., Lingel, A., Lin, Y., Liu, Y., Luo, F., Shi, M., Wang, L., Wang, Z., Yu, Y., Zeng, J., Zeng, C., Zhang, L., Zhang, Q., Zhou, S., Oyang, C., Atadja, P., Li, E. Nat. Chem. Biol.