CATH Domain 5fahA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.117

Stratum corneum chymotryptic enzyme.

based on mapping to UniProt P49862

Cleavage of proteins with aromatic side chains in the P1 position.

-!- This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the alpha-chain of native human fibrinogen. -!- It cleaves the B chain of bovine insulin at 6-Leu-|-Cya-7 (cysteic acid), 16-Tyr-|-Leu-17, 25-Phe-|-Tyr-26 and 26-Tyr-|-Thr-27. -!- It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures. -!- Belongs to peptidase family S1A.

UniProtKB Entries (1)

P49862

KLK7_HUMAN

Homo sapiens

Kallikrein-7

PDB Structure

PDB	5FAH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small-molecule factor D inhibitors targeting the alternative complement pathway. Maibaum, J., Liao, S.M., Vulpetti, A., Ostermann, N., Randl, S., Rudisser, S., Lorthiois, E., Erbel, P., Kinzel, B., Kolb, F.A., Barbieri, S., Wagner, J., Durand, C., Fettis, K., Dussauge, S., Hughes, N., Delgado, O., Hommel, U., Gould, T., Mac Sweeney, A., Gerhartz, B., Cumin, F., Flohr, S., Schubart, A., Jaffee, B., Harrison, R., Risitano, A.M., Eder, J., Anderson, K. Nat.Chem.Biol.