CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1120 | Arylsulfatase, C-terminal domain |
|
3.30.1120.30 | POLO box domain |
Domain Context
CATH Clusters
| Superfamily | POLO box domain |
| Functional Family | Serine/threonine-protein kinase PLK |
Enzyme Information
| 2.7.11.21 |
Polo kinase.
based on mapping to UniProt Q07832
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| Q8CDI2 |
FBX43_MOUSE
Mus musculus
F-box only protein 43
|
PDB Structure
| PDB | 5DMS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization.
Sci Rep
|
