CATH Domain 5agrA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.740	Isoleucyl-tRNA Synthetase; domain 2
	3.90.740.10	Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain

Domain Context

CATH Clusters

Superfamily	Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Functional Family	Leucine--tRNA ligase

Enzyme Information

6.1.1.4

Leucine--tRNA ligase.

based on mapping to UniProt P9WFV1

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

UniProtKB Entries (1)

SYL_MYCTU

Mycobacterium tuberculosis H37Rv

Leucine--tRNA ligase

PDB Structure

PDB	5AGR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase. Palencia, A., Li, X., Bu, W., Choi, W., Ding, C.Z., Easom, E.E., Feng, L., Hernandez, V., Houston, P., Liu, L., Meewan, M., Mohan, M., Rock, F.L., Sexton, H., Zhang, S., Zhou, Y., Wan, B., Wang, Y., Franzblau, S.G., Woolhiser, L., Gruppo, V., Lenaerts, A.J., O'Malley, T., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Ioerger, T.R., Sacchettini, J.C., Rullas, J., Angulo-Barturen, I., Perez-Herran, E., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J., Alley, M.R.K. Antimicrob.Agents Chemother.