CATH Domain 5a83A00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.920	Histone Acetyltransferase; Chain A
	1.20.920.10	Bromodomain-like

Domain Context

CATH Clusters

Superfamily	Bromodomain-like
Functional Family	ATPase family AAA domain-containing protein 2

Enzyme Information

3.6.1.3

Adenosinetriphosphatase.

based on mapping to UniProt Q6PL18

ATP + H(2)O = ADP + phosphate.

-!- Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39. -!- The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA. -!- Formerly EC 3.6.1.4.

UniProtKB Entries (1)

Q6PL18

ATAD2_HUMAN

Homo sapiens

ATPase family AAA domain-containing protein 2

PDB Structure

PDB	5A83
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Optimization of Naphthyridones Into Potent Atad2 Bromodomain Inhibitors. Bamborough, P., Chung, C., Furze, R.C., Grandi, P., Michon, A., Sheppard, R.J., Barnett, H., Diallo, H., Dixon, D.P., Douault, C., Jones, E.J., Karamshi, B., Mitchell, D.J., Prinjha, R.K., Rau, C., Watson, R.J., Werner, T., Demont, E.H. J.Med.Chem.